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Gene Review

WDR12  -  WD repeat domain 12

Homo sapiens

Synonyms: FLJ10881, Ribosome biogenesis protein WDR12, WD repeat-containing protein 12, YTM1
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High impact information on WDR12

  • Further, a conditionally expressed dominant-negative mutant of WDR12 also blocks rRNA processing and induces a reversible cell cycle arrest [1].
  • Endogenous WDR12, a WD40 repeat protein, is crucial for processing of the 32S precursor ribosomal RNA (rRNA) and cell proliferation [1].
  • Wdr12 seems to correspond to a single-copy gene in the mouse genome, located within the C1-C2 bands of chromosome 1 [2].


  1. Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation. Hölzel, M., Rohrmoser, M., Schlee, M., Grimm, T., Harasim, T., Malamoussi, A., Gruber-Eber, A., Kremmer, E., Hiddemann, W., Bornkamm, G.W., Eick, D. J. Cell Biol. (2005) [Pubmed]
  2. Wdr12, a mouse gene encoding a novel WD-Repeat Protein with a notchless-like amino-terminal domain. Nal, B., Mohr, E., Silva, M.I., Tagett, R., Navarro, C., Carroll, P., Depetris, D., Verthuy, C., Jordan, B.R., Ferrier, P. Genomics (2002) [Pubmed]
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