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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

DOK5  -  docking protein 5

Homo sapiens

Synonyms: C20orf180, Docking protein 5, Downstream of tyrosine kinase 5, IRS-6, IRS6, ...
 
 
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High impact information on DOK5

  • IRS6/DOK5 expression is highest in skeletal muscle [1].
  • Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5 [1].
  • EGFR expression levels were low (IRS 0 to 5) in 83 patients (90%) and high (IRS 6 to 7) in 9 patients (10%) [2].
  • Dok5 co-localized with TrkB and TrkC in differentiated PC12 cells, providing another evidence for their interaction [3].
  • Taken together, these results suggest that Dok5 acts as substrate of TrkB/C receptors and is involved in neurotrophin induced MAPK signal pathway activation [3].
 

Other interactions of DOK5

  • These genes are the orthologues of mouse Dok4 and Dok5 genes [4].

References

  1. Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5. Cai, D., Dhe-Paganon, S., Melendez, P.A., Lee, J., Shoelson, S.E. J. Biol. Chem. (2003) [Pubmed]
  2. Epidermal growth factor receptor as a prognostic factor in locally advanced rectal-cancer patients treated with preoperative chemoradiation. Li, S., Kim, J.S., Kim, J.M., Cho, M.J., Yoon, W.H., Song, K.S., Yeo, S.G., Kim, J.S. Int. J. Radiat. Oncol. Biol. Phys. (2006) [Pubmed]
  3. Dok5 is substrate of TrkB and TrkC receptors and involved in neurotrophin induced MAPK activation. Shi, L., Yue, J., You, Y., Yin, B., Gong, Y., Xu, C., Qiang, B., Yuan, J., Liu, Y., Peng, X. Cell. Signal. (2006) [Pubmed]
  4. DOK4 and DOK5: new Dok-related genes expressed in human T cells. Favre, C., Gérard, A., Clauzier, E., Pontarotti, P., Olive, D., Nunès, J.A. Genes Immun. (2003) [Pubmed]
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