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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

DCAF6  -  DDB1 and CUL4 associated factor 6

Homo sapiens

Synonyms: 1200006M05Rik, ARCAP, Androgen receptor complex-associated protein, DDB1-and CUL4-associated factor 6, IQ motif and WD repeat-containing protein 1, ...
 
 
 
 
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High impact information on IQWD1

  • We found NRIP interacts with either androgen or glucocorticoid receptors from in vitro and in vivo pulldown assays [1].
  • Subsequently, transient transfection and luciferase activity assays suggested that NRIP was a ligand-dependent coactivator of steroid receptors (androgen and glucocorticoid) in distinct promoters [1].
  • To further clarify the function of NRIP, we found an RNA interference-3-targeted NRIP gene sequence (5'-GATGATACAGCACGAGAAC-3') that could efficiently and specifically knock down endogenous and exogenous NRIP gene expression and that significantly diminished cell proliferation in prostate (LNCaP) and cervical (C33A) cells [1].

References

  1. NRIP, a novel nuclear receptor interaction protein, enhances the transcriptional activity of nuclear receptors. Tsai, T.C., Lee, Y.L., Hsiao, W.C., Tsao, Y.P., Chen, S.L. J. Biol. Chem. (2005) [Pubmed]
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