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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Stx5a  -  syntaxin 5A

Mus musculus

Synonyms: 0610031F24Rik, D19Ertd627e, Stx5, Syntaxin-5, syntaxin 5
 
 
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Psychiatry related information on Stx5a

  • Among familial Alzheimer's disease (FAD)-linked PS mutants, PS1deltaE9, which lacks the endoproteolytic cleavage site, showed markedly decreased binding to Syx 5 [1].
 

High impact information on Stx5a

  • Syx 5, which localizes from the endoplasmic reticulum (ER) to the Golgi, bound to PS holoproteins, while the other Syxs studied did not [1].
  • We therefore set out to identify the molecular determinants for localizing several syntaxin isoforms, including syntaxins 3, 4, and 5, to their respective intracellular compartments (plasma membrane for syntaxins 3 and 4; cis-Golgi for syntaxin 5) [2].
  • Furthermore, truncation of the syntaxin 3 transmembrane domain to 17 amino acids resulted in a complete conversion to cis-Golgi compartmentalization that was indistinguishable from syntaxin 5 [2].

References

  1. Syntaxin 5 interacts specifically with presenilin holoproteins and affects processing of betaAPP in neuronal cells. Suga, K., Saito, A., Tomiyama, T., Mori, H., Akagawa, K. J. Neurochem. (2005) [Pubmed]
  2. Transmembrane domain length determines intracellular membrane compartment localization of syntaxins 3, 4, and 5. Watson, R.T., Pessin, J.E. Am. J. Physiol., Cell Physiol. (2001) [Pubmed]
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