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Gene Review

Stx5  -  syntaxin 5

Rattus norvegicus

Synonyms: Stx5a, Syntaxin-5
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High impact information on Stx5a


Biological context of Stx5a

  • In the NAc shell, morphine administration resulted in upregulation of caspace 9, NF-kappaB, NF-H, tau, GABA-A delta subunit, FGFR1, Ggamma2, synuclein 1, syntaxin 5 and 13, GRK5, and c-fos mRNAs [6].

Anatomical context of Stx5a

  • To extend these observations we have now cloned a protein from rat liver membranes which forms a native complex with syntaxin 5 [7].
  • Additionally, we find that syntaxins 6, 7 and 8, but not syntaxin 5, are present at the plasma membrane, and that these syntaxins cycle through the plasma membrane by virtue of their cytoplasmic domains [8].

Associations of Stx5a with chemical compounds

  • Previously it had been shown that p97-mediated reassembly of Golgi cisternae from mitotic Golgi fragments requires p47 which mediates the binding of p97 to a Golgi t-SNARE (soluble N-ethylmaleimide-sensitive factor attachment factor receptor), syntaxin 5 [9].

Physical interactions of Stx5a

  • Three-dimensional structure of the rSly1 N-terminal domain reveals a conformational change induced by binding to syntaxin 5 [10].

Other interactions of Stx5a

  • Comparison with the crystal structure of a complex between Sly1p and Sed5p, their yeast homologues, shows that syntaxin 5 binding requires a striking conformational change involving a two-residue shift in the register of the C-terminal beta-strand of rSly1N [10].
  • Here we demonstrate that hsc70 chaperones stimulate in vitro SNARE complex formation among the ER/Golgi SNAREs syntaxin 5, membrin, rbetl and sec22b, under conditions in which assembly is normally inhibited [11].


  1. Role of vesicle-associated syntaxin 5 in the assembly of pre-Golgi intermediates. Rowe, T., Dascher, C., Bannykh, S., Plutner, H., Balch, W.E. Science (1998) [Pubmed]
  2. Tyrosine phosphorylation of p97 regulates transitional endoplasmic reticulum assembly in vitro. Lavoie, C., Chevet, E., Roy, L., Tonks, N.K., Fazel, A., Posner, B.I., Paiement, J., Bergeron, J.J. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  3. The identification of a novel endoplasmic reticulum to Golgi SNARE complex used by the prechylomicron transport vesicle. Siddiqi, S.A., Siddiqi, S., Mahan, J., Peggs, K., Gorelick, F.S., Mansbach, C.M. J. Biol. Chem. (2006) [Pubmed]
  4. Role of p97 and syntaxin 5 in the assembly of transitional endoplasmic reticulum. Roy, L., Bergeron, J.J., Lavoie, C., Hendriks, R., Gushue, J., Fazel, A., Pelletier, A., Morré, D.J., Subramaniam, V.N., Hong, W., Paiement, J. Mol. Biol. Cell (2000) [Pubmed]
  5. An isoform of the Golgi t-SNARE, syntaxin 5, with an endoplasmic reticulum retrieval signal. Hui, N., Nakamura, N., Sönnichsen, B., Shima, D.T., Nilsson, T., Warren, G. Mol. Biol. Cell (1997) [Pubmed]
  6. Morphine-induced alterations in gene expression of calbindin immunopositive neurons in nucleus accumbens shell and core. Hemby, S.E. Neuroscience (2004) [Pubmed]
  7. Mammalian Sly1 regulates syntaxin 5 function in endoplasmic reticulum to Golgi transport. Dascher, C., Balch, W.E. J. Biol. Chem. (1996) [Pubmed]
  8. Roles of the cytoplasmic and transmembrane domains of syntaxins in intracellular localization and trafficking. Kasai, K., Akagawa, K. J. Cell. Sci. (2001) [Pubmed]
  9. The p47 co-factor regulates the ATPase activity of the membrane fusion protein, p97. Meyer, H.H., Kondo, H., Warren, G. FEBS Lett. (1998) [Pubmed]
  10. Three-dimensional structure of the rSly1 N-terminal domain reveals a conformational change induced by binding to syntaxin 5. Araç, D., Dulubova, I., Pei, J., Huryeva, I., Grishin, N.V., Rizo, J. J. Mol. Biol. (2005) [Pubmed]
  11. Evidence for regulation of ER/Golgi SNARE complex formation by hsc70 chaperones. Joglekar, A.P., Hay, J.C. Eur. J. Cell Biol. (2005) [Pubmed]
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