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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Syx5  -  Syntaxin 5

Drosophila melanogaster

Synonyms: BG:DS02740.12, CG4214, DmSyx5, Dmel\CG4214, II, ...
 
 
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High impact information on Syx5

  • GATE-16 is essential for NSF-driven Golgi reassembly and precludes GOS-28 from binding to its cognate t-SNARE, syntaxin-5 [1].
  • A similar distribution was obtained with a chimeric molecule consisting of a plasma membrane syntaxin with the Drosophila Sed5 transmembrane domain [2].
  • The yeast Sed5 protein, which is required for vesicular transport between ER and Golgi complex, is a membrane protein of the syntaxin family [2].
  • Furthermore, this phenotype persisted when the mutation was combined with a second mutation that greatly reduced syntaxin binding affinity [3].
  • Syntaxin 5 is required for cytokinesis and spermatid differentiation in Drosophila [4].
 

Biological context of Syx5

  • Syntaxin 5 is a Golgi-localized SNARE protein that has been shown to be required for ER-Golgi traffic in yeast and Golgi reassembly following cell division in mammalian cells [4].
  • Drosophila syntaxin is required for cell viability and may function in membrane formation and stabilization [5].
  • Syntaxin probably interacts with multiple proteins during synaptic vesicle exocytosis [6].

References

  1. Sequential SNARE disassembly and GATE-16-GOS-28 complex assembly mediated by distinct NSF activities drives Golgi membrane fusion. Muller, J.M., Shorter, J., Newman, R., Deinhardt, K., Sagiv, Y., Elazar, Z., Warren, G., Shima, D.T. J. Cell Biol. (2002) [Pubmed]
  2. Localization of Sed5, a putative vesicle targeting molecule, to the cis-Golgi network involves both its transmembrane and cytoplasmic domains. Banfield, D.K., Lewis, M.J., Rabouille, C., Warren, G., Pelham, H.R. J. Cell Biol. (1994) [Pubmed]
  3. Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions. Ciufo, L.F., Barclay, J.W., Burgoyne, R.D., Morgan, A. Mol. Biol. Cell (2005) [Pubmed]
  4. Syntaxin 5 is required for cytokinesis and spermatid differentiation in Drosophila. Xu, H., Brill, J.A., Hsien, J., McBride, R., Boulianne, G.L., Trimble, W.S. Dev. Biol. (2002) [Pubmed]
  5. Drosophila syntaxin is required for cell viability and may function in membrane formation and stabilization. Schulze, K.L., Bellen, H.J. Genetics (1996) [Pubmed]
  6. The relation of protein binding to function: what is the significance of munc18 and synaptotagmin binding to syntaxin 1, and where are the corresponding binding sites? Matos, M.F., Rizo, J., Südhof, T.C. Eur. J. Cell Biol. (2000) [Pubmed]
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