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Gene Review

Stx3  -  syntaxin 3

Mus musculus

Synonyms: AA960228, AV006285, AW536415, Stx3a, Syn-3, ...
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High impact information on Stx3


Biological context of Stx3

  • These forms of syntaxin 3 are probably generated by alternative splicing of the primary transcript of syntaxin 3 gene [5].
  • cDNAs for four different forms of syntaxin 3 were cloned from a mouse brain cDNA library, and the proteins encoded by these clones were named syntaxin 3A (previous syntaxin 3), 3B, 3C and 3D [5].

Anatomical context of Stx3

  • We summarize here data on the presence and the functional role of vesicle transport proteins in the kidney, and describe work addressing the developmentally regulated expression and localization of three molecules suggested to be involved in polarized trafficking in kidney epithelia, Rab17, syntaxin 3, and Munc-18-2 [6].
  • Syntaxin 3 was found in glutamatergic photoreceptor and bipolar cell ribbon synapses, but was absent from putative conventional glutamatergic amacrine cell synapses [7].

Analytical, diagnostic and therapeutic context of Stx3


  1. Syntaxin-3 and syntaxin-1A inhibit L-type calcium channel activity, insulin biosynthesis and exocytosis in beta-cell lines. Kang, Y., Huang, X., Pasyk, E.A., Ji, J., Holz, G.G., Wheeler, M.B., Tsushima, R.G., Gaisano, H.Y. Diabetologia (2002) [Pubmed]
  2. Syntaxin 3 and Munc-18-2 in epithelial cells during kidney development. Lehtonen, S., Riento, K., Olkkonen, V.M., Lehtonen, E. Kidney Int. (1999) [Pubmed]
  3. Initial entry of IRAP into the insulin-responsive storage compartment occurs prior to basal or insulin-stimulated plasma membrane recycling. Liu, G., Hou, J.C., Watson, R.T., Pessin, J.E. Am. J. Physiol. Endocrinol. Metab. (2005) [Pubmed]
  4. Transmembrane domain length determines intracellular membrane compartment localization of syntaxins 3, 4, and 5. Watson, R.T., Pessin, J.E. Am. J. Physiol., Cell Physiol. (2001) [Pubmed]
  5. Identification of four different forms of syntaxin 3. Ibaraki, K., Horikawa, H.P., Morita, T., Mori, H., Sakimura, K., Mishina, M., Saisu, H., Abe, T. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  6. Vesicular transport and kidney development. Lehtonen, S., Lehtonen, E., Olkkonen, V.M. Int. J. Dev. Biol. (1999) [Pubmed]
  7. Distribution of plasma membrane-associated syntaxins 1 through 4 indicates distinct trafficking functions in the synaptic layers of the mouse retina. Sherry, D.M., Mitchell, R., Standifer, K.M., du Plessis, B. BMC neuroscience [electronic resource]. (2006) [Pubmed]
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