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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Nudt3  -  nudix (nucleotide diphosphate linked...

Mus musculus

Synonyms: 1110011B09Rik, AA960325, DIPP-1, Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1, Diphosphoinositol polyphosphate phosphohydrolase 1, ...
 
 
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High impact information on Nudt3

  • Our laboratory reported that the transcription factor p53 stimulates the terminal differentiation of renal epithelial cells by means of transcriptional activation of renal function genes (Saifudeen Z, Dipp S, and El-Dahr SS. J Clin Invest 109: 1021-1030, 2002) [1].
  • Conversely, gestational high salt suppresses the fetal renin-angiotensin system (RAS) and provokes aberrant renal development in bradykinin B(2)-KO mice (El-Dahr SS, Harrison-Bernard LM, Dipp S, Yosipiv IV, and Meleg-Smith S, Physiol Genomics 3: 121-131, 2000) [2].
  • Inhibition of signal transduction through the ERK1/2 pathway by muDIPP1 occurs at or downstream from activation of MEK [3].
  • While these studies were in progress, the human homologue of this gene was characterized as diphosphoinositol polyphosphate phosphohydrolase (DIPP1) [EMBO J. 17 (1998) 6599], a phosphohydrolase that converts diphosphate groups on diphosphoinositol polyphosphates to monophosphates [3].

References

  1. Spatial repression of PCNA by p53 during kidney development. Saifudeen, Z., Marks, J., Du, H., El-Dahr, S.S. Am. J. Physiol. Renal Physiol. (2002) [Pubmed]
  2. Targeted disruption of the bradykinin B(2) receptor gene in mice alters the ontogeny of the renin-angiotensin system. Yosipiv, I.V., Dipp, S., El-Dahr, S.S. Am. J. Physiol. Renal Physiol. (2001) [Pubmed]
  3. Ectopic expression of murine diphosphoinositol polyphosphate phosphohydrolase 1 attenuates signaling through the ERK1/2 pathway. Chu, C., Alapat, D., Wen, X., Timo, K., Burstein, D., Lisanti, M., Shears, S., Kohtz, D.S. Cell. Signal. (2004) [Pubmed]
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