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Gene Review:

ERO1LB - ERO1-like beta (S. cerevisiae)

Homo sapiens

Synonyms: ERO1-L(beta), ERO1-L-beta, ERO1-like protein beta, Endoplasmic reticulum oxidoreductin-1-like protein B, Oxidoreductin-1-L-beta

Pagani, M. et al., Gess, B. et al., Mezghrani, A. et al.

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Disease relevance of ERO1LB

We report here that the expression of the rat, mouse and human homologues of ERO1-Like protein alpha but not of the isoform ERO1-Lbeta are stimulated by hypoxia in rats vivo and in rat, mouse and human cell cultures [1].

High impact information on ERO1LB

Here we show that both human Ero1-Lalpha and Ero1-Lbeta (hEROs) facilitate disulfide bond formation in immunoglobulin subunits by selectively oxidizing PDI [2].
ERO1-L and ERO1-Lbeta display different tissue distributions [3].
Endoplasmic reticulum oxidoreductin 1-lbeta (ERO1-Lbeta), a human gene induced in the course of the unfolded protein response [3].
Activation of the unfolded protein response (UPR) by tunicamycin, on the other hand, strongly induced ERO1-Lbeta and more moderately ERO1-Lalpha expression [1].

Analytical, diagnostic and therapeutic context of ERO1LB

Immunofluorescence, endoglycosidase sensitivity, and in vitro translation/translocation assays reveal that the products of the ERO1-Lbeta gene are primarily localized in the ER of mammalian cells [3].

References

The cellular oxygen tension regulates expression of the endoplasmic oxidoreductase ERO1-Lalpha. Gess, B., Hofbauer, K.H., Wenger, R.H., Lohaus, C., Meyer, H.E., Kurtz, A. Eur. J. Biochem. (2003) [Pubmed]
Manipulation of oxidative protein folding and PDI redox state in mammalian cells. Mezghrani, A., Fassio, A., Benham, A., Simmen, T., Braakman, I., Sitia, R. EMBO J. (2001) [Pubmed]
Endoplasmic reticulum oxidoreductin 1-lbeta (ERO1-Lbeta), a human gene induced in the course of the unfolded protein response. Pagani, M., Fabbri, M., Benedetti, C., Fassio, A., Pilati, S., Bulleid, N.J., Cabibbo, A., Sitia, R. J. Biol. Chem. (2000) [Pubmed]

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AgaP_AGAP002816	Anopheles gambiae str. PEST
ERO1LB	Bos taurus
ero-1	Caenorhabditis elegans
ERO1LB	Canis lupus familiaris
ero1lb	Danio rerio
Ero1L	Drosophila melanogaster
ERO1LB	Gallus gallus
Ero1lb	Mus musculus
ERO1LB	Pan troglodytes
Ero1lb	Rattus norvegicus
ero1l	Xenopus (Silurana) tropicalis

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