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Chemical Compound Review

tunicamycin     N-[(2R,3R,4R,5S,6R)-2- [(2R,3R,4R,5S,6R)-3...

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Disease relevance of tunicamycin


Psychiatry related information on tunicamycin

  • An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease [6].
  • Results of biosynthetic labeling of BF0.3, 615.2, and Id 150 in the presence and absence of tunicamycin suggest that the difference in m.w. and charge observed between alpha m and alpha s can be attributed to differences in primary amino acid structure rather than different degrees of glycosylation [7].

High impact information on tunicamycin


Chemical compound and disease context of tunicamycin


Biological context of tunicamycin


Anatomical context of tunicamycin


Associations of tunicamycin with other chemical compounds


Gene context of tunicamycin

  • Over-expression of a dominant-negative form of Ire1 blocks the induction of GRP78/BiP and CHOP in response to the ER stress induced by tunicamycin treatment [27].
  • Knockdown of endogenous ATF4 or CHOP expression dramatically repressed tunicamycin-induced TRB3 induction [28].
  • In many, but not in all cases, CD44 does not bind HA unless it is stimulated by phorbol esters, activated by agonistic anti-CD44 antibody, or deglycosylated (e.g., by tunicamycin) [29].
  • Enforced overexpression of cyclin D1 in tunicamycin-treated cells maintained cyclin D- and E-dependent kinase activities and kept cells in cycle in the face of a fully activated UPR [30].
  • By using N-glycosidase F, tunicamycin, and specific antibodies produced in both chicken and rabbit, we demonstrate that PlGF, derived from transfected COS-1 cells, is actually N-glycosylated and secreted into the medium [31].

Analytical, diagnostic and therapeutic context of tunicamycin


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  2. CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Marciniak, S.J., Yun, C.Y., Oyadomari, S., Novoa, I., Zhang, Y., Jungreis, R., Nagata, K., Harding, H.P., Ron, D. Genes Dev. (2004) [Pubmed]
  3. CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Zinszner, H., Kuroda, M., Wang, X., Batchvarova, N., Lightfoot, R.T., Remotti, H., Stevens, J.L., Ron, D. Genes Dev. (1998) [Pubmed]
  4. Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway. Reimertz, C., Kögel, D., Rami, A., Chittenden, T., Prehn, J.H. J. Cell Biol. (2003) [Pubmed]
  5. Cod1p/Spf1p is a P-type ATPase involved in ER function and Ca2+ homeostasis. Cronin, S.R., Rao, R., Hampton, R.Y. J. Cell Biol. (2002) [Pubmed]
  6. An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease. Onuki, R., Bando, Y., Suyama, E., Katayama, T., Kawasaki, H., Baba, T., Tohyama, M., Taira, K. EMBO J. (2004) [Pubmed]
  7. Membrane-bound and secreted IgA contain structurally different alpha-chains. Sitia, R., Kikutani, H., Rubartelli, A., Bushkin, Y., Stavnezer, J., Hammerling, U. J. Immunol. (1982) [Pubmed]
  8. Transforming growth factor-beta controls receptor levels for epidermal growth factor in NRK fibroblasts. Assoian, R.K., Frolik, C.A., Roberts, A.B., Miller, D.M., Sporn, M.B. Cell (1984) [Pubmed]
  9. Analysis of the hemagglutinin glycoprotein from mutants of vaccinia virus that accumulates on the nuclear envelope. Shida, H., Matsumoto, S. Cell (1983) [Pubmed]
  10. Biosynthesis of the major zona pellucida glycoprotein secreted by oocytes during mammalian oogenesis. Greve, J.M., Salzmann, G.S., Roller, R.J., Wassarman, P.M. Cell (1982) [Pubmed]
  11. Glycoprotein synthesis and inhibition of glycosylation by tunicamycin in preimplantation mouse embryos: compaction and trophoblast adhesion. Surani, M.A. Cell (1979) [Pubmed]
  12. Loss of melanogenic properties in tyrosinases induced by glucosylation inhibitors within malignant melanoma cells. Imokawa, G., Mishima, Y. Cancer Res. (1982) [Pubmed]
  13. Gadd45 and Gadd153 messenger RNA levels are increased during hypoxia and after exposure of cells to agents which elevate the levels of the glucose-regulated proteins. Price, B.D., Calderwood, S.K. Cancer Res. (1992) [Pubmed]
  14. Transcriptional regulation and the effects of sodium butyrate and glycosylation on catalytic activity of human germ cell alkaline phosphatase. Pan, C.J., Sartwell, A.D., Chou, J.Y. Cancer Res. (1991) [Pubmed]
  15. Human melanoma-associated antigens: role of carbohydrate in shedding and cell surface expression. Morgan, A.C., Galloway, D.R., Imai, K., Reisfeld, R.A. J. Immunol. (1981) [Pubmed]
  16. The nature of hemopoietic histocompatibility determinants. Differential sensitivity of Hh-1b and H-2b determinants to tunicamycin. Milisauskas, V.K., Nakamura, I. J. Immunol. (1988) [Pubmed]
  17. Photoreceptor-specific degeneration caused by tunicamycin. Fliesler, S.J., Rapp, L.M., Hollyfield, J.G. Nature (1984) [Pubmed]
  18. Tunicamycin enhances the antiviral and anticellular activity of interferon. Maheshwari, R.K., Sreevalsan, T., Silverman, R.H., Hay, J., Friedman, R.M. Science (1983) [Pubmed]
  19. Secretion in yeast: in vitro analysis of the sec53 mutant. Hibbs, A.R., Meyer, D.I. EMBO J. (1988) [Pubmed]
  20. Synthesis and mobilization of flagellar glycoproteins during regeneration in Euglena. Geetha-Habib, M., Bouck, G.B. J. Cell Biol. (1982) [Pubmed]
  21. Role of carbohydrates in protein secretion and turnover: effects of tunicamycin on the major cell surface glycoprotein of chick embryo fibroblasts. Olden, K., Pratt, R.M., Yamada, K.M. Cell (1978) [Pubmed]
  22. Inhibition of invariant chain (Ii)-calnexin interaction results in enhanced degradation of Ii but does not prevent the assembly of alpha beta Ii complexes. Romagnoli, P., Germain, R.N. J. Exp. Med. (1995) [Pubmed]
  23. Characterization of HLA-D-region antigens by two-dimensional gel electrophoresis. Molecular-genotyping. Charron, D.J., McDevitt, H.O. J. Exp. Med. (1980) [Pubmed]
  24. Demonstration of structural polymorphism among HLA-DR light chains by two-dimensional gel electrophoresis. Shackelford, D.A., Strominger, J.L. J. Exp. Med. (1980) [Pubmed]
  25. Acetaldehyde impairs mitochondrial glutathione transport in HepG2 cells through endoplasmic reticulum stress. Lluis, J.M., Colell, A., García-Ruiz, C., Kaplowitz, N., Fernández-Checa, J.C. Gastroenterology (2003) [Pubmed]
  26. Biosynthesis and processing of platelet GPIIb-IIIa in human megakaryocytes. Duperray, A., Berthier, R., Chagnon, E., Ryckewaert, J.J., Ginsberg, M., Plow, E., Marguerie, G. J. Cell Biol. (1987) [Pubmed]
  27. Cloning of mammalian Ire1 reveals diversity in the ER stress responses. Wang, X.Z., Harding, H.P., Zhang, Y., Jolicoeur, E.M., Kuroda, M., Ron, D. EMBO J. (1998) [Pubmed]
  28. TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. Ohoka, N., Yoshii, S., Hattori, T., Onozaki, K., Hayashi, H. EMBO J. (2005) [Pubmed]
  29. CD44: structure, function, and association with the malignant process. Naor, D., Sionov, R.V., Ish-Shalom, D. Adv. Cancer Res. (1997) [Pubmed]
  30. Mammalian unfolded protein response inhibits cyclin D1 translation and cell-cycle progression. Brewer, J.W., Hendershot, L.M., Sherr, C.J., Diehl, J.A. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  31. Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor. Maglione, D., Guerriero, V., Viglietto, G., Delli-Bovi, P., Persico, M.G. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  32. Acquisition of cytotoxic T lymphocyte-specific carbohydrate differentiation antigens. Lefrancois, L., Puddington, L., Machamer, C.E., Bevan, M.J. J. Exp. Med. (1985) [Pubmed]
  33. The relationship of N-linked glycosylation and heavy chain-binding protein association with the secretion of glycoproteins. Dorner, A.J., Bole, D.G., Kaufman, R.J. J. Cell Biol. (1987) [Pubmed]
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