Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

MUC13 - mucin 13, cell surface associated

Homo sapiens

Synonyms: DRCC1, Down-regulated in colon cancer 1, MUC-13, Mucin-13, RECC, ...

Williams, S.J. et al., Lang, T. et al.

Lang, Hansson, Samuelsson,

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High impact information on MUC13

Including MUC13, there are at least five cell surface mucins expressed in the gastrointestinal tract [1].
MUC13 mRNA is expressed most highly in the large intestine and trachea, and at moderate levels in the kidney, small intestine, appendix, and stomach [1].
Immunohistochemistry demonstrated the human MUC13 protein on the apical membrane of both columnar and goblet cells in the gastrointestinal tract, as well as within goblet cell thecae, indicative of secretion in addition to presence on the cell surface [1].
Unlike previously known mucins, the PTS domain of Muc13 is encoded by multiple exons, where each exon encodes a repeat unit of the PTS domain [2].
HEG has PTS, EGF and transmembrane domains like Muc13, suggesting that these two proteins are evolutionary related [2].

Biological context of MUC13

An inventory of mucin genes in the chicken genome shows that the mucin domain of Muc13 is encoded by multiple exons and that ovomucin is part of a locus of related gel-forming mucins [2].

References

Muc13, a novel human cell surface mucin expressed by epithelial and hemopoietic cells. Williams, S.J., Wreschner, D.H., Tran, M., Eyre, H.J., Sutherland, G.R., McGuckin, M.A. J. Biol. Chem. (2001) [Pubmed]
An inventory of mucin genes in the chicken genome shows that the mucin domain of Muc13 is encoded by multiple exons and that ovomucin is part of a locus of related gel-forming mucins. Lang, T., Hansson, G.C., Samuelsson, T. BMC Genomics (2006) [Pubmed]

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