The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Intestine, Large

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Intestine, Large


Psychiatry related information on Intestine, Large


High impact information on Intestine, Large

  • The principal VFA in either the rumen or large intestine are acetate, propionate, and butyrate and are produced in a ratio varying from approximately 75:15:10 to 40:40:20 [7].
  • These potential amoebic virulence determinants were also toxic to human colonic epithelial cells, the primary cellular targets in amoebal invasion of the large intestine [8].
  • The site of adenosine 3',5'-monophosphate-mediated fluid and electrolyte secretion across mammalian large intestine was found to be the crypts of Lieberkühn by means of two techniques [9].
  • Lung and kidney contained 2-5% and large intestine contained nearly 10% of SAA mRNA levels found in liver RNA [10].
  • Our laboratory has previously demonstrated that 1,25-dihydroxyvitamin D3 (1,25[OH]2D3) rapidly stimulated polyphosphoinositide (PI) hydrolysis, raised intracellular Ca2+, and activated two Ca2+-dependent protein kinase C (PKC) isoforms, PKC-alpha and -betaII in the rat large intestine [11].

Chemical compound and disease context of Intestine, Large


Biological context of Intestine, Large


Anatomical context of Intestine, Large


Associations of Intestine, Large with chemical compounds


Gene context of Intestine, Large


Analytical, diagnostic and therapeutic context of Intestine, Large


  1. Confirmation of the two-step nature of chemical carcinogenesis in the rat colon adenocarcinoma model. Maskens, A.P. Cancer Res. (1981) [Pubmed]
  2. Regulation of constitutive cyclooxygenase-2 expression in colon carcinoma cells. Shao, J., Sheng, H., Inoue, H., Morrow, J.D., DuBois, R.N. J. Biol. Chem. (2000) [Pubmed]
  3. Hapten-induced model of murine inflammatory bowel disease: mucosa immune responses and protection by tolerance. Elson, C.O., Beagley, K.W., Sharmanov, A.T., Fujihashi, K., Kiyono, H., Tennyson, G.S., Cong, Y., Black, C.A., Ridwan, B.W., McGhee, J.R. J. Immunol. (1996) [Pubmed]
  4. Genetic analysis of Escherichia coli K1 gastrointestinal colonization. Martindale, J., Stroud, D., Moxon, E.R., Tang, C.M. Mol. Microbiol. (2000) [Pubmed]
  5. Intestinal excretion of oxalate in chronic renal failure. Hatch, M., Freel, R.W., Vaziri, N.D. J. Am. Soc. Nephrol. (1994) [Pubmed]
  6. Psychological and sex features of delayed gut transit in functional gastrointestinal disorders. Bennett, E.J., Evans, P., Scott, A.M., Badcock, C.A., Shuter, B., Höschl, R., Tennant, C.C., Kellow, J.E. Gut (2000) [Pubmed]
  7. Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. Bergman, E.N. Physiol. Rev. (1990) [Pubmed]
  8. Coding of hemolysins within the ribosomal RNA repeat on a plasmid in Entamoeba histolytica. Jansson, A., Gillin, F., Kagardt, U., Hagblom, P. Science (1994) [Pubmed]
  9. Crypts are the site of intestinal fluid and electrolyte secretion. Welsh, M.J., Smith, P.L., Fromm, M., Frizzell, R.A. Science (1982) [Pubmed]
  10. Amyloid A gene family expression in different mouse tissues. Meek, R.L., Benditt, E.P. J. Exp. Med. (1986) [Pubmed]
  11. 1,25 dihydroxyvitamin D3 stimulates phospholipase C-gamma in rat colonocytes: role of c-Src in PLC-gamma activation. Khare, S., Bolt, M.J., Wali, R.K., Skarosi, S.F., Roy, H.K., Niedziela, S., Scaglione-Sewell, B., Aquino, B., Abraham, C., Sitrin, M.D., Brasitus, T.A., Bissonnette, M. J. Clin. Invest. (1997) [Pubmed]
  12. Identification of coccoid Escherichia coli BJ4 cells in the large intestine of streptomycin-treated mice. Krogfelt, K.A., Poulsen, L.K., Molin, S. Infect. Immun. (1993) [Pubmed]
  13. Escherichia coli F-18 makes a streptomycin-treated mouse large intestine colonization factor when grown in nutrient broth containing glucose. Cohen, P.S., Kjelleberg, S., Laux, D.C., Conway, P.L. Infect. Immun. (1990) [Pubmed]
  14. An Escherichia coli MG1655 lipopolysaccharide deep-rough core mutant grows and survives in mouse cecal mucus but fails to colonize the mouse large intestine. Møller, A.K., Leatham, M.P., Conway, T., Nuijten, P.J., de Haan, L.A., Krogfelt, K.A., Cohen, P.S. Infect. Immun. (2003) [Pubmed]
  15. Pharmacokinetics of nitrate in humans: role of gastrointestinal absorption and metabolism. Schultz, D.S., Deen, W.M., Karel, S.F., Wagner, D.A., Tannenbaum, S.R. Carcinogenesis (1985) [Pubmed]
  16. Melatonin content in plasma and large intestine of patients with colorectal carcinoma before and after surgery. Vician, M., Zeman, M., Herichová, I., Juráni, M., Blazícek, P., Matis, P. J. Pineal Res. (1999) [Pubmed]
  17. The keratin 19 promoter is potent for cell-specific targeting of genes in transgenic mice. Brembeck, F.H., Moffett, J., Wang, T.C., Rustgi, A.K. Gastroenterology (2001) [Pubmed]
  18. Relationship of a non-cystic fibrosis transmembrane conductance regulator-mediated chloride conductance to organ-level disease in Cftr(-/-) mice. Clarke, L.L., Grubb, B.R., Yankaskas, J.R., Cotton, C.U., McKenzie, A., Boucher, R.C. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  19. Comparison of the effects of an ornithine decarboxylase inhibitor on the intestinal epithelium and on intestinal tumors. Tutton, P.J., Barkla, D.H. Cancer Res. (1986) [Pubmed]
  20. Essential requirement for Pax6 in control of enteroendocrine proglucagon gene transcription. Hill, M.E., Asa, S.L., Drucker, D.J. Mol. Endocrinol. (1999) [Pubmed]
  21. Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage. Sivakumar, P.V., Westrich, G.M., Kanaly, S., Garka, K., Born, T.L., Derry, J.M., Viney, J.L. Gut (2002) [Pubmed]
  22. Organ distribution of the three rat endothelin messenger RNAs and the effects of ischemia on renal gene expression. Firth, J.D., Ratcliffe, P.J. J. Clin. Invest. (1992) [Pubmed]
  23. Carcinogenicity test of six nitrosamides and a nitrosocyanamide administered orally to rats. Bulay, O., Mirvish, S.S., Garcia, H., Pelfrene, A.F., Gold, B., Eagen, M. J. Natl. Cancer Inst. (1979) [Pubmed]
  24. Developmental expression and functionality of hepatocyte growth factor and c-Met in human fetal digestive tissues. Kermorgant, S., Walker, F., Hormi, K., Dessirier, V., Lewin, M.J., Lehy, T. Gastroenterology (1997) [Pubmed]
  25. Functional characteristics of lymphocytes isolated from the rat large intestine. Response to T-cell mitogens and natural killer cell activity. Nauss, K.M., Pavlina, T.M., Kumar, V., Newberne, P.M. Gastroenterology (1984) [Pubmed]
  26. Electrogenic Na+/HCO3- cotransporters: cloning and physiology. Romero, M.F., Boron, W.F. Annu. Rev. Physiol. (1999) [Pubmed]
  27. Nondegradation of fecal cholesterol in subjects at high risk for cancer of the large intestine. Lipkin, M., Reddy, B.S., Weisburger, J., Schechter, L. J. Clin. Invest. (1981) [Pubmed]
  28. Methylated DNA adducts in the large intestine of ICR/Ha and C57BL/Ha mice given 1,2-dimethylhydrazine. James, J.T., Autrup, H. J. Natl. Cancer Inst. (1983) [Pubmed]
  29. Inhibition of dimethylhydrazine-induced neoplasia of the large intestine by disulfiram. Wattenberg, L.W. J. Natl. Cancer Inst. (1975) [Pubmed]
  30. Inhibitory effects of butylated hydroxyanisole on methylazoxymethanol acetate-induced neoplasia of the large intestine and on nicotinamide adenine dinucleotide-dependent alcohol dehydrogenase activity in mice. Wattenberg, L.W., Sparnins, V.L. J. Natl. Cancer Inst. (1979) [Pubmed]
  31. Differential cellular expression of the human MSH2 repair enzyme in small and large intestine. Wilson, T.M., Ewel, A., Duguid, J.R., Eble, J.N., Lescoe, M.K., Fishel, R., Kelley, M.R. Cancer Res. (1995) [Pubmed]
  32. Serum amyloid A in the mouse. Sites of uptake and mRNA expression. Meek, R.L., Eriksen, N., Benditt, E.P. Am. J. Pathol. (1989) [Pubmed]
  33. Differences in intraepithelial lymphocyte T cell subsets isolated from murine small versus large intestine. Beagley, K.W., Fujihashi, K., Lagoo, A.S., Lagoo-Deenadaylan, S., Black, C.A., Murray, A.M., Sharmanov, A.T., Yamamoto, M., McGhee, J.R., Elson, C.O. J. Immunol. (1995) [Pubmed]
  34. O-glycosylated MUC2 monomer and dimer from LS 174T cells are water-soluble, whereas larger MUC2 species formed early during biosynthesis are insoluble and contain nonreducible intermolecular bonds. Axelsson, M.A., Asker, N., Hansson, G.C. J. Biol. Chem. (1998) [Pubmed]
  35. Prenatal blockage of lymphotoxin beta receptor and TNF receptor p55 signaling cascade resulted in the acceleration of tissue genesis for isolated lymphoid follicles in the large intestine. Kweon, M.N., Yamamoto, M., Rennert, P.D., Park, E.J., Lee, A.Y., Chang, S.Y., Hiroi, T., Nanno, M., Kiyono, H. J. Immunol. (2005) [Pubmed]
  36. cDNA cloning, functional expression, and mRNA tissue distribution of a third organellar Ca2+ pump. Burk, S.E., Lytton, J., MacLennan, D.H., Shull, G.E. J. Biol. Chem. (1989) [Pubmed]
  37. Correlation of variations in intraluminal pressure and potential differences in the perfused colen. Postaire, J.G., Gerard, J., Devroede, G., Van Houtte, N. Gut (1977) [Pubmed]
  38. In situ distribution of transforming growth factor alpha in normal human tissues and in malignant tumours of the ovary. Kommoss, F., Wintzer, H.O., Von Kleist, S., Kohler, M., Walker, R., Langton, B., Van Tran, K., Pfleiderer, A., Bauknecht, T. J. Pathol. (1990) [Pubmed]
  39. The importance of the stomach in gastrin-induced hypocalcemia in the rat. Schulak, J.A., Kaplan, E.L. Endocrinology (1975) [Pubmed]
  40. Comparative alterations in p53 expression and apoptosis in the irradiated rat small and large intestine. Arai, T., Kida, Y., Harmon, B.V., Gobé, G.C. Br. J. Cancer (1996) [Pubmed]
WikiGenes - Universities