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Gene Review:

PSG4 - pregnancy specific beta-1-glycoprotein 4

Homo sapiens

Synonyms: CGM4, PS-beta-G-4, PS-beta-G-9, PSBG-4, PSBG-9, ...

Kaighn, M.E. et al., Plouzek, C.A. et al., Zimmermann, W. et al., Pan, C.J. et al.

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High impact information on PSG4

BudR stimulated the expression of all PSG transcripts except PSG4 [1].
To circumvent the problems associated with the use of serum, two serum-free media (CGM-4 and CGM-9) were developed [2].
They are derived from three closely related genes (PSG1, PSG4 and PSG6) [3].

Anatomical context of PSG4

Ribonuclease protection analyses show that PSG mRNAs that share sequence similarity with the PSG9 transcript are expressed in both human placenta and placental fibroblasts [4].
However, significant differential responses of the individual cell lines to CGM-4 and CGM-9 were observed, whereas, in serum-supplemented medium all three lines responded similarly [2].

References

Pregnancy-specific glycoprotein gene expression and the induction by 5-bromo-2'-deoxyuridine. Pan, C.J., Chamberlin, M.E., Wu, S.M., Chan, W.Y., Chou, J.Y. Biochemistry (1994) [Pubmed]
Differential growth control of normal, preneoplastic and neoplastic Syrian hamster embryo cells in serum-free media. Kaighn, M.E., Kumari, H.L., Spalding, J.W., Barrett, J.C., Iype, P.T. Carcinogenesis (1993) [Pubmed]
cDNA cloning demonstrates the expression of pregnancy-specific glycoprotein genes, a subgroup of the carcinoembryonic antigen gene family, in fetal liver. Zimmermann, W., Weiss, M., Thompson, J.A. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
Cloning and expression of a new pregnancy-specific beta 1-glycoprotein member. Plouzek, C.A., Watanabe, S., Chou, J.Y. Biochem. Biophys. Res. Commun. (1991) [Pubmed]

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