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Gene Review

PSG6  -  pregnancy specific beta-1-glycoprotein 6

Homo sapiens

Synonyms: CGM3, PS-beta-G-10, PS-beta-G-12, PS-beta-G-6, PSBG-10, ...
 
 
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Disease relevance of PSG6

  • Northern blot hybridization performed with a PSGGB-specific oligonucleotide probe to the N domain revealed that PSGGB or a PSGGB-like gene encodes a major 1.7-kilobase mRNA in hydatidiform mole tissues and a major 2.0-kilobase mRNA in term placenta tissues [1].
 

High impact information on PSG6

  • PSGGB corresponds to the previously identified cDNA PSG6, which encodes proteins containing a 34-amino acid leader peptide and a 108-amino acid N domain, which is one amino acid shorter than the majority of PS beta G N domains [1].
  • Depending upon the domains compared, PSGGA and PSGGB share 92-98% nucleotide and 86-95% amino acid sequence identity with PSG93, the most abundant PS beta G transcript [1].
  • Additionally, the PSGGB-encoded proteins contain the cell-surface recognition tripeptide Arg-Gly-Asp, shared by several previously reported PS beta Gs as deduced from cDNA sequences [1].
  • To characterize PSG promoter activity, we constructed chloramphenicol acetyltransferase (CAT) fusion genes containing -809 to -44 basepairs up-stream of the translational start site of the PSG6 gene [2].
  • The N-terminal domain of PSG6 was sufficient for induction of monocyte cytokine secretion [3].

References

  1. Linkage of two human pregnancy-specific beta 1-glycoprotein genes: one is associated with hydatidiform mole. Leslie, K.K., Watanabe, S., Lei, K.J., Chou, D.Y., Plouzek, C.A., Deng, H.C., Torres, J., Chou, J.Y. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  2. Immortalization of virus-free human placental cells that express tissue-specific functions. Lei, K.J., Gluzman, Y., Pan, C.J., Chou, J.Y. Mol. Endocrinol. (1992) [Pubmed]
  3. Pregnancy-specific glycoproteins function as immunomodulators by inducing secretion of IL-10, IL-6 and TGF-beta1 by human monocytes. Snyder, S.K., Wessner, D.H., Wessells, J.L., Waterhouse, R.M., Wahl, L.M., Zimmermann, W., Dveksler, G.S. Am. J. Reprod. Immunol. (2001) [Pubmed]
 
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