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Gene Review

BDH2  -  3-hydroxybutyrate dehydrogenase, type 2

Homo sapiens

Synonyms: 3-hydroxybutyrate dehydrogenase type 2, DHRS6, Dehydrogenase/reductase SDR family member 6, EFA6R, FLJ13261, ...
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High impact information on BDH2

  • The properties determined for DHRS6 suggest a possible physiological role in cytosolic ketone body utilization, either as a secondary system for energy supply in starvation or to generate precursors for lipid and sterol synthesis [1].
  • Human DHRS6 is a previously uncharacterized member of the short chain dehydrogenases/reductase family and displays significant homologies to bacterial hydroxybutyrate dehydrogenases [1].


  1. Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta-hydroxybutyrate dehydrogenase. Guo, K., Lukacik, P., Papagrigoriou, E., Meier, M., Lee, W.H., Adamski, J., Oppermann, U. J. Biol. Chem. (2006) [Pubmed]
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