The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Somsanit     4-hydroxybutanoate

Synonyms: Anetamin, Hydroxyb, Oxybate, Xyrem, Gamma OH, ...
This record was replaced with 10413.
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Sodium oxybate


Psychiatry related information on Sodium oxybate


High impact information on Sodium oxybate


Chemical compound and disease context of Sodium oxybate


Biological context of Sodium oxybate


Anatomical context of Sodium oxybate


Associations of Sodium oxybate with other chemical compounds


Gene context of Sodium oxybate


Analytical, diagnostic and therapeutic context of Sodium oxybate


  1. The protective effect of gamma-hydroxybutyrate in regional intestinal ischemia in the hamster. Boyd, A.J., Sherman, I.A., Saibil, F.G., Mamelak, M. Gastroenterology (1990) [Pubmed]
  2. Effect of 3-hydroxybutyrate in obese subjects on very-low-energy diets and during therapeutic starvation. Pawan, G.L., Semple, S.J. Lancet (1983) [Pubmed]
  3. Murine succinate semialdehyde dehydrogenase deficiency. Gupta, M., Hogema, B.M., Grompe, M., Bottiglieri, T.G., Concas, A., Biggio, G., Sogliano, C., Rigamonti, A.E., Pearl, P.L., Snead, O.C., Jakobs, C., Gibson, K.M. Ann. Neurol. (2003) [Pubmed]
  4. A novel gamma-hydroxybutyrate dehydrogenase: identification and expression of an Arabidopsis cDNA and potential role under oxygen deficiency. Breitkreuz, K.E., Allan, W.L., Van Cauwenberghe, O.R., Jakobs, C., Talibi, D., Andre, B., Shelp, B.J. J. Biol. Chem. (2003) [Pubmed]
  5. Life-threatening interactions between HIV-1 protease inhibitors and the illicit drugs MDMA and gamma-hydroxybutyrate. Harrington, R.D., Woodward, J.A., Hooton, T.M., Horn, J.R. Arch. Intern. Med. (1999) [Pubmed]
  6. Simultaneous stimulation of slow-wave sleep and growth hormone secretion by gamma-hydroxybutyrate in normal young Men. Van Cauter, E., Plat, L., Scharf, M.B., Leproult, R., Cespedes, S., L'Hermite-Balériaux, M., Copinschi, G. J. Clin. Invest. (1997) [Pubmed]
  7. gamma-Hydroxybutyrate in narcolepsy. Price, P.A., Schachter, M., Smith, S.J., Baxter, R.C., Parkes, J.D. Ann. Neurol. (1981) [Pubmed]
  8. Gamma-hydroxybutyrate dependence with social phobia. Trendelenburg, G., Heinz, A., Ströhle, A. The American journal of psychiatry. (2004) [Pubmed]
  9. "Grievous bodily harm:" gamma hydroxybutyrate abuse leading to a Wernicke-Korsakoff syndrome. Friedman, J., Westlake, R., Furman, M. Neurology (1996) [Pubmed]
  10. Effect of genetically caused excess of brain gamma-hydroxybutyric acid and GABA on sleep. Arnulf, I., Konofal, E., Gibson, K.M., Rabier, D., Beauvais, P., Derenne, J.P., Philippe, A. Sleep. (2005) [Pubmed]
  11. Adverse events, including death, associated with the use of 1,4-butanediol. Zvosec, D.L., Smith, S.W., McCutcheon, J.R., Spillane, J., Hall, B.J., Peacock, E.A. N. Engl. J. Med. (2001) [Pubmed]
  12. Effect of gamma-hydroxybutyrate on the reactivity of pial arteries before and after ischemia. Haller, C., Kuschinsky, W., Reimnitz, P. J. Cereb. Blood Flow Metab. (1986) [Pubmed]
  13. The impact of donor chemical overdose on the outcome of liver transplantation. Komokata, T., Nishida, S., Ganz, S., Suzuki, T., Olson, L., Tzakis, A.G. Transplantation (2003) [Pubmed]
  14. The gamma-hydroxybutyrate model of absence seizures: correlation of regional brain levels of gamma-hydroxybutyric acid and gamma-butyrolactone with spike wave discharges. Snead, O.C. Neuropharmacology (1991) [Pubmed]
  15. GABAB(1) Receptor Subunit Isoforms Exert a Differential Influence on Baseline but Not GABAB Receptor Agonist-Induced Changes in Mice. Jacobson, L.H., Bettler, B., Kaupmann, K., Cryan, J.F. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  16. Purification and properties of 4-hydroxybutyrate coenzyme A transferase from Clostridium aminobutyricum. Scherf, U., Buckel, W. Appl. Environ. Microbiol. (1991) [Pubmed]
  17. Kinetics of coupled gamma-hydroxybutyrate oxidation and D-glucuronate reduction by an NADP+-dependent oxidoreductase. Kaufman, E.E., Nelson, T. J. Biol. Chem. (1981) [Pubmed]
  18. Gamma-hydroxybutyrate reduces mitogen-activated protein kinase phosphorylation via GABA B receptor activation in mouse frontal cortex and hippocampus. Ren, X., Mody, I. J. Biol. Chem. (2003) [Pubmed]
  19. GHB depresses fast excitatory and inhibitory synaptic transmission via GABA(B) receptors in mouse neocortical neurons. Jensen, K., Mody, I. Cereb. Cortex (2001) [Pubmed]
  20. The gamma-hydroxybutyrate signalling system in brain: organization and functional implications. Maitre, M. Prog. Neurobiol. (1997) [Pubmed]
  21. Effects of sustained gamma-hydroxybutyrate treatments on spontaneous and evoked firing activity of locus coeruleus norepinephrine neurons. Szabo, S.T., Gold, M.S., Goldberger, B.A., Blier, P. Biol. Psychiatry (2004) [Pubmed]
  22. Gamma hydroxybutyrate in the monkey. I. Electroencephalographic, behavioral, and pharmacokinetic studies. Snead, O.C. Neurology (1978) [Pubmed]
  23. Effects of gamma-hydroxybutrate and gamma-butyrolactone on cerebral energy metabolism during exposure and recovery from hypoxemia-oligemia. MacMillan, V. Stroke (1980) [Pubmed]
  24. The metabolic response to yellow fever immunization: protein-sparing modified fast. Bistrian, B.R., George, D.T., Blackburn, G.L., Wannemacher, R.W. Am. J. Clin. Nutr. (1981) [Pubmed]
  25. Conversion of gamma-hydroxybutyrate to gamma-aminobutyrate in vitro. Vayer, P., Mandel, P., Maitre, M. J. Neurochem. (1985) [Pubmed]
  26. Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta-hydroxybutyrate dehydrogenase. Guo, K., Lukacik, P., Papagrigoriou, E., Meier, M., Lee, W.H., Adamski, J., Oppermann, U. J. Biol. Chem. (2006) [Pubmed]
  27. Pharmacological profiles of generalized absence seizures in lethargic, stargazer and gamma-hydroxybutyrate-treated model mice. Aizawa, M., Ito, Y., Fukuda, H. Neurosci. Res. (1997) [Pubmed]
  28. Effect of halothane anesthesia on muscle, liver, thyroid, and adrenal-function tests in man. Johnstone, R.E., Kennell, E.M., Brummund, W., Shaw, L.M., Ebersole, R.C. Clin. Chem. (1976) [Pubmed]
  29. Construction of environmental DNA libraries in Escherichia coli and screening for the presence of genes conferring utilization of 4-hydroxybutyrate. Henne, A., Daniel, R., Schmitz, R.A., Gottschalk, G. Appl. Environ. Microbiol. (1999) [Pubmed]
  30. Significance of serum tumor markers in patients with carcinoma of the ovary. Kikuchi, Y., Kizawa, I., Koyama, E., Kato, K. Obstetrics and gynecology. (1984) [Pubmed]
  31. Naloxone overcomes the dopaminergic, EEG, and behavioral effects of gamma-hydroxybutyrate. Snead, O.C., Bearden, L.J. Neurology (1980) [Pubmed]
  32. Efficacy of gamma-hydroxybutyrate versus placebo in treating narcolepsy-cataplexy: double-blind subjective measures. Scrima, L., Hartman, P.G., Johnson, F.H., Hiller, F.C. Biol. Psychiatry (1989) [Pubmed]
  33. Extracellular events induced by gamma-hydroxybutyrate in striatum: a microdialysis study. Hechler, V., Gobaille, S., Bourguignon, J.J., Maitre, M. J. Neurochem. (1991) [Pubmed]
  34. The effects of gamma-hydroxybutyrate on the sleep of narcolepsy patients: a double-blind study. Scrima, L., Hartman, P.G., Johnson, F.H., Thomas, E.E., Hiller, F.C. Sleep. (1990) [Pubmed]
  35. Gamma-hydroxybutyrate and cocaine administration increases mRNA expression of dopamine D1 and D2 receptors in rat brain. Schmidt-Mutter, C., Muller, C., Zwiller, J., Gobaille, S., Maitre, M. Neuropsychopharmacology (1999) [Pubmed]
WikiGenes - Universities