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Gene Review

PGLYRP4  -  peptidoglycan recognition protein 4

Homo sapiens

Synonyms: PGLYRPIbeta, PGRP-I-beta, PGRP-Ibeta, PGRPIB, Peptidoglycan recognition protein 4, ...
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Disease relevance of PGLYRP4


High impact information on PGLYRP4


Biological context of PGLYRP4


Anatomical context of PGLYRP4

  • PGLYRP-1 is expressed primarily in the granules of polymorphonuclear leucocytes (PMNs) , and PGLYRP-3 and PGLYRP-4 are expressed in the skin, eyes, salivary glands, throat, tongue, esophagus, stomach and intestine, and protect the host against infections [4].


  1. Peptidoglycan recognition proteins are a new class of human bactericidal proteins. Lu, X., Wang, M., Qi, J., Wang, H., Li, X., Gupta, D., Dziarski, R. J. Biol. Chem. (2006) [Pubmed]
  2. Peptidoglycan recognition proteins Pglyrp3 and Pglyrp4 are encoded from the epidermal differentiation complex and are candidate genes for the Psors4 locus on chromosome 1q21. Sun, C., Mathur, P., Dupuis, J., Tizard, R., Ticho, B., Crowell, T., Gardner, H., Bowcock, A.M., Carulli, J. Hum. Genet. (2006) [Pubmed]
  3. Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules. Liu, C., Xu, Z., Gupta, D., Dziarski, R. J. Biol. Chem. (2001) [Pubmed]
  4. Mammalian PGRPs: novel antibacterial proteins. Dziarski, R., Gupta, D. Cell. Microbiol. (2006) [Pubmed]
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