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Gene Review

PGLYRP1  -  peptidoglycan recognition protein 1

Homo sapiens

Synonyms: PGLYRP, PGRP, PGRP-S, PGRPS, Peptidoglycan recognition protein 1, ...
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Disease relevance of PGLYRP1


High impact information on PGLYRP1


Chemical compound and disease context of PGLYRP1


Biological context of PGLYRP1


Anatomical context of PGLYRP1

  • In mammals one PGRP is an antibacterial neutrophil protein [14].
  • PGLYRP-1 is expressed primarily in the granules of polymorphonuclear leucocytes (PMNs) , and PGLYRP-3 and PGLYRP-4 are expressed in the skin, eyes, salivary glands, throat, tongue, esophagus, stomach and intestine, and protect the host against infections [15].
  • These PAMPs definitely activated nuclear factor (NF)-kappaB in the epithelial cells, and suppression of NF-kappaB activation clearly prevented the induction of PGRP mRNA expression induced by these PAMPs in the cells [16].
  • Peptidoglycan recognition protein tag7 forms a cytotoxic complex with heat shock protein 70 in solution and in lymphocytes [17].
  • In insects, PGRP recognizes bacterial cell wall peptidoglycan (PGN) and activates prophenoloxidase cascade, a part of the insect antimicrobial defense system [13].

Associations of PGLYRP1 with chemical compounds


Other interactions of PGLYRP1


Analytical, diagnostic and therapeutic context of PGLYRP1


  1. Crystal structure of human peptidoglycan recognition protein I{alpha} bound to a muramyl pentapeptide from Gram-positive bacteria. Guan, R., Brown, P.H., Swaminathan, C.P., Roychowdhury, A., Boons, G.J., Mariuzza, R.A. Protein Sci. (2006) [Pubmed]
  2. A peptidoglycan recognition protein in innate immunity conserved from insects to humans. Kang, D., Liu, G., Lundström, A., Gelius, E., Steiner, H. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  3. Human peptidoglycan recognition protein S is an effector of neutrophil-mediated innate immunity. Cho, J.H., Fraser, I.P., Fukase, K., Kusumoto, S., Fujimoto, Y., Stahl, G.L., Ezekowitz, R.A. Blood (2005) [Pubmed]
  4. The peptidoglycan recognition proteins (PGRPs). Dziarski, R., Gupta, D. Genome Biol. (2006) [Pubmed]
  5. The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein. Gottar, M., Gobert, V., Michel, T., Belvin, M., Duyk, G., Hoffmann, J.A., Ferrandon, D., Royet, J. Nature (2002) [Pubmed]
  6. Dual strategies for peptidoglycan discrimination by peptidoglycan recognition proteins (PGRPs). Swaminathan, C.P., Brown, P.H., Roychowdhury, A., Wang, Q., Guan, R., Silverman, N., Goldman, W.E., Boons, G.J., Mariuzza, R.A. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  7. Structural basis for preferential recognition of diaminopimelic acid-type peptidoglycan by a subset of peptidoglycan recognition proteins. Lim, J.H., Kim, M.S., Kim, H.E., Yano, T., Oshima, Y., Aggarwal, K., Goldman, W.E., Silverman, N., Kurata, S., Oh, B.H. J. Biol. Chem. (2006) [Pubmed]
  8. Crystal structure of a peptidoglycan recognition protein (PGRP) in complex with a muramyl tripeptide from Gram-positive bacteria. Guan, R., Roychowdury, A., Ember, B., Kumar, S., Boons, G.J., Mariuzza, R.A. J. Endotoxin Res. (2005) [Pubmed]
  9. Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules. Liu, C., Xu, Z., Gupta, D., Dziarski, R. J. Biol. Chem. (2001) [Pubmed]
  10. Crystal structure of the C-terminal peptidoglycan-binding domain of human peptidoglycan recognition protein Ialpha. Guan, R., Malchiodi, E.L., Wang, Q., Schuck, P., Mariuzza, R.A. J. Biol. Chem. (2004) [Pubmed]
  11. Crystal structure of human peptidoglycan recognition protein S (PGRP-S) at 1.70 A resolution. Guan, R., Wang, Q., Sundberg, E.J., Mariuzza, R.A. J. Mol. Biol. (2005) [Pubmed]
  12. Host PGRP Gene Expression and Bacterial Release in Endosymbiosis of the Weevil Sitophilus zeamais. Anselme, C., Vallier, A., Balmand, S., Fauvarque, M.O., Heddi, A. Appl. Environ. Microbiol. (2006) [Pubmed]
  13. Mammalian peptidoglycan recognition protein binds peptidoglycan with high affinity, is expressed in neutrophils, and inhibits bacterial growth. Liu, C., Gelius, E., Liu, G., Steiner, H., Dziarski, R. J. Biol. Chem. (2000) [Pubmed]
  14. Human peptidoglycan recognition protein-L is an N-acetylmuramoyl-L-alanine amidase. Wang, Z.M., Li, X., Cocklin, R.R., Wang, M., Wang, M., Fukase, K., Inamura, S., Kusumoto, S., Gupta, D., Dziarski, R. J. Biol. Chem. (2003) [Pubmed]
  15. Mammalian PGRPs: novel antibacterial proteins. Dziarski, R., Gupta, D. Cell. Microbiol. (2006) [Pubmed]
  16. Chemically synthesized pathogen-associated molecular patterns increase the expression of peptidoglycan recognition proteins via toll-like receptors, NOD1 and NOD2 in human oral epithelial cells. Uehara, A., Sugawara, Y., Kurata, S., Fujimoto, Y., Fukase, K., Kusumoto, S., Satta, Y., Sasano, T., Sugawara, S., Takada, H. Cell. Microbiol. (2005) [Pubmed]
  17. Peptidoglycan recognition protein tag7 forms a cytotoxic complex with heat shock protein 70 in solution and in lymphocytes. Sashchenko, L.P., Dukhanina, E.A., Yashin, D.V., Shatalov, Y.V., Romanova, E.A., Korobko, E.V., Demin, A.V., Lukyanova, T.I., Kabanova, O.D., Khaidukov, S.V., Kiselev, S.L., Gabibov, A.G., Gnuchev, N.V., Georgiev, G.P. J. Biol. Chem. (2004) [Pubmed]
  18. Selective recognition of synthetic lysine and meso-diaminopimelic acid-type peptidoglycan fragments by human peptidoglycan recognition proteins I{alpha} and S. Kumar, S., Roychowdhury, A., Ember, B., Wang, Q., Guan, R., Mariuzza, R.A., Boons, G.J. J. Biol. Chem. (2005) [Pubmed]
  19. Bioaerosols and innate immune responses in airway diseases. Hauswirth, D.W., Sundy, J.S. Current opinion in allergy and clinical immunology. (2004) [Pubmed]
  20. Identification of immunorelevant genes from greater wax moth (Galleria mellonella) by a subtractive hybridization approach. Seitz, V., Clermont, A., Wedde, M., Hummel, M., Vilcinskas, A., Schlatterer, K., Podsiadlowski, L. Dev. Comp. Immunol. (2003) [Pubmed]
  21. NMR structure of Citrobacter freundii AmpD, comparison with bacteriophage T7 lysozyme and homology with PGRP domains. Liepinsh, E., Généreux, C., Dehareng, D., Joris, B., Otting, G. J. Mol. Biol. (2003) [Pubmed]
  22. Phase I/II trial of gene therapy with autologous tumor cells modified with tag7/PGRP-S gene in patients with disseminated solid tumors: miscellaneous tumors. Moiseyenko, V.M., Danilov, A.O., Baldueva, I.A., Danilova, A.B., Tyukavina, N.V., Larin, S.S., Kiselev, S.L., Orlova, R.V., Anisimov, V.V., Semenova, A.I., Shchekina, L.A., Gafton, G.I., Kochnev, V.A., Barchuk, A.S., Kanaev, S.V., Hanson, K.P., Georgiev, G.P. Ann. Oncol. (2005) [Pubmed]
  23. Molecular cloning and mRNA expression of peptidoglycan recognition protein (PGRP) gene in bay scallop (Argopecten irradians, Lamarck 1819). Ni, D., Song, L., Wu, L., Chang, Y., Yu, Y., Qiu, L., Wang, L. Dev. Comp. Immunol. (2007) [Pubmed]
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