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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ADAMTSL3  -  ADAMTS-like 3

Homo sapiens

Synonyms: ADAMTS-like protein 3, ADAMTSL-3, KIAA1233, Punctin-2, punctin-2
 
 
 
 
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High impact information on ADAMTSL3

  • Northern blot analysis of RNA from human adult tissues demonstrated that ADAMTSL3 is widely expressed, with highest expression in liver, kidney, heart and skeletal muscle, whereas it is expressed at low levels in mouse embryos [1].
  • The domain structure of punctin-2 and its matrix localization suggest that it might play a role in cell-matrix interactions or in assembly of specific extracellular matrices [1].
  • Using these and a monoclonal antibody to a C-terminal myc tag, we show that in transfected COS-7 cells, punctin-2 is expressed as a 210-kDa glycoprotein that is located in the extracellular matrix [1].

References

  1. ADAMTSL-3/punctin-2, a novel glycoprotein in extracellular matrix related to the ADAMTS family of metalloproteases. Hall, N.G., Klenotic, P., Anand-Apte, B., Apte, S.S. Matrix Biol. (2003) [Pubmed]
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