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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Isl2  -  ISL LIM homeobox 2

Rattus norvegicus

Synonyms: Insulin gene enhancer protein ISL-2, Isl-2, Islet-2
 
 
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High impact information on Isl2

  • We have cloned a family of LIM homeobox genes in chick and show here that the combinatorial expression of four of these genes, Islet-1, Islet-2, Lim-1, and Lim-3, defines subclasses of motor neurons that segregate into columns in the spinal cord and select distinct axonal pathways [1].
  • We find that activated RARbeta up-regulates islet-1 expression, whereas activation of RARalpha can either act in combination with RARbeta signalling to maintain islet-1 expression or induce islet-2 expression in the absence of activated RARbeta [2].

References

  1. Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes. Tsuchida, T., Ensini, M., Morton, S.B., Baldassare, M., Edlund, T., Jessell, T.M., Pfaff, S.L. Cell (1994) [Pubmed]
  2. Timing of the retinoid-signalling pathway determines the expression of neuronal markers in neural progenitor cells. Goncalves, M.B., Boyle, J., Webber, D.J., Hall, S., Minger, S.L., Corcoran, J.P. Dev. Biol. (2005) [Pubmed]
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