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Gene Review

Isl2  -  ISL LIM homeobox 2

Rattus norvegicus

Synonyms: Insulin gene enhancer protein ISL-2, Isl-2, Islet-2
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High impact information on Isl2

  • We have cloned a family of LIM homeobox genes in chick and show here that the combinatorial expression of four of these genes, Islet-1, Islet-2, Lim-1, and Lim-3, defines subclasses of motor neurons that segregate into columns in the spinal cord and select distinct axonal pathways [1].
  • We find that activated RARbeta up-regulates islet-1 expression, whereas activation of RARalpha can either act in combination with RARbeta signalling to maintain islet-1 expression or induce islet-2 expression in the absence of activated RARbeta [2].


  1. Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes. Tsuchida, T., Ensini, M., Morton, S.B., Baldassare, M., Edlund, T., Jessell, T.M., Pfaff, S.L. Cell (1994) [Pubmed]
  2. Timing of the retinoid-signalling pathway determines the expression of neuronal markers in neural progenitor cells. Goncalves, M.B., Boyle, J., Webber, D.J., Hall, S., Minger, S.L., Corcoran, J.P. Dev. Biol. (2005) [Pubmed]
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