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Gene Review

ISL2  -  ISL LIM homeobox 2

Homo sapiens

Synonyms: FLJ10160, Insulin gene enhancer protein ISL-2, Islet-2
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High impact information on ISL2

  • We cloned and characterized the ISL2 and LHX2 LIM-homeodomain transcription factors of the Mexican salamander, or axolotl, Ambystoma mexicanum [1].
  • Other LIM-homeobox proteins (Lim-1, -2 and -3 and Islet-2) are not expressed either in normal or Frorieps' DRG at early stages of development [2].


  1. Cloning and analysis of axolotl ISL2 and LHX2 LIM-homeodomain transcription factors. Showalter, A.D., Yaden, B.C., Chernoff, E.A., Rhodes, S.J. Genesis (2004) [Pubmed]
  2. Differences in neuronal differentiation between the transient cranial (Frorieps') and normal dorsal root ganglia. Avivi, C., Cui, S., Goren, S., Goldstein, R.S. Brain Res. Dev. Brain Res. (2002) [Pubmed]
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