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Gene Review

isl2a  -  ISL LIM homeobox 2a

Danio rerio

Synonyms: ISL-2, Insulin gene enhancer protein isl-2, Insulin gene enhancer protein isl-2a, Islet-2, Islet-2A, ...
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Disease relevance of isl2a


High impact information on isl2a

  • Islet-2 is a LIM/homeodomain-type transcription factor of the Islet-1 family expressed in embryonic zebrafish [2].
  • Two Islet-2 molecules bind to the LIM domain binding protein (Ldb) dimers [2].
  • This suggests that zfIsl-3 may be involved in the regional specification of the myotome and also in target recognition by CaP. zfIsl-2 is also expressed throughout the developing eye and tectal region of the midbrain, the target for the retinal axons [3].
  • Involvement of Islet-2 in the Slit signaling for axonal branching and defasciculation of the sensory neurons in embryonic zebrafish [4].

Anatomical context of isl2a

  • In the ventral spinal cord of the spadetail mutant embryo, which has defects in the somites, the cells expressing zfIsl-2 mRNA significantly decreased in number in contrast to the increase in cells expressing Isl-1 mRNA, suggesting the influence of the somites on the expression of both genes [3].


  1. Presence of isl-1-related LIM domain homeobox genes in teleost and their similar patterns of expression in brain and spinal cord. Gong, Z., Hui, C.C., Hew, C.L. J. Biol. Chem. (1995) [Pubmed]
  2. Functional repression of Islet-2 by disruption of complex with Ldb impairs peripheral axonal outgrowth in embryonic zebrafish. Segawa, H., Miyashita, T., Hirate, Y., Higashijima, S., Chino, N., Uyemura, K., Kikuchi, Y., Okamoto, H. Neuron (2001) [Pubmed]
  3. Molecular heterogeneity among primary motoneurons and within myotomes revealed by the differential mRNA expression of novel islet-1 homologs in embryonic zebrafish. Tokumoto, M., Gong, Z., Tsubokawa, T., Hew, C.L., Uyemura, K., Hotta, Y., Okamoto, H. Dev. Biol. (1995) [Pubmed]
  4. Involvement of Islet-2 in the Slit signaling for axonal branching and defasciculation of the sensory neurons in embryonic zebrafish. Yeo, S.Y., Miyashita, T., Fricke, C., Little, M.H., Yamada, T., Kuwada, J.Y., Huh, T.L., Chien, C.B., Okamoto, H. Mech. Dev. (2004) [Pubmed]
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