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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

NMRAL1  -  NmrA-like family domain containing 1

Homo sapiens

Synonyms: FLJ25918, HSCARG, NmrA-like family domain-containing protein 1, SDR48A1
 
 
 
 
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Disease relevance of NMRAL1

  • In order to investigate its structure and function, HSCARG gene has been successfully expressed and purified in E. coli [1].
 

Associations of NMRAL1 with chemical compounds

  • A decrease in the NADPH/NADP(+) ratio, induced by dehydroepiandrosterone treatment, enhanced the interaction between HSCARG and AS, which resulted in stronger inhibition of AS activity and nitric oxide production [2].
 

Analytical, diagnostic and therapeutic context of NMRAL1

References

  1. Protein Expression, Crystallization and Preliminary X-Ray Crystallographic Studies on HSCARG from Homo Sapiens. Dai, X., Gu, X., Luo, M., Zheng, X. Protein Pept. Lett. (2006) [Pubmed]
  2. An NADPH sensor protein (HSCARG) down-regulates nitric oxide synthesis by association with argininosuccinate synthetase and is essential for epithelial cell viability. Zhao, Y., Zhang, J., Li, H., Li, Y., Ren, J., Luo, M., Zheng, X. J. Biol. Chem. (2008) [Pubmed]
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