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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Humans


High impact information on Humans

  • The genetic legacy of Paleolithic Homo sapiens sapiens in extant Europeans: a Y chromosome perspective [6].
  • Fossils and artifacts recovered from the middle Awash Valley of Ethiopia's Afar depression sample the Middle Pleistocene transition from Homo erectus to Homo sapiens [7].
  • We describe here a new human peptide deformylase (Homo sapiens PDF, or HsPDF) that is localized to the mitochondria [8].
  • A novel approximately 60-residue domain has been identified in Homo sapiens MGC5297 and various other proteins in eukaryotes [9].
  • Two homologues of TIP1 in yeast (Saccharomyces cerevisiae) and human (Homo sapiens) have been shown to have S-acyl transferase (also known as palmitoyl transferase) activity [10].

Chemical compound and disease context of Humans


Biological context of Humans


Anatomical context of Humans


Associations of Humans with chemical compounds


Gene context of Humans

  • The experiments described here show that Homo sapiens (Hs)Rad52 and yeast Rad52 proteins promote strand exchange as well [25].
  • In this report we describe the isolation of the wild-type Homo sapiens (Hs)ORC and variants containing a Walker A motif mutation in the Orc1, Orc4, or Orc5 subunit using the baculovirus-expression system [26].
  • Cyclin B3 (CCNB3) is conserved from Caenorhabditis elegans to Homo sapiens and has an undefined meiotic function in female, but not male Drosophila melanogaster [27].
  • Phylogenetic and dot plot analyses for the RECQ family, including 10 eukaryotic and 3 prokaryotic genes, indicate Dmblm is most closely related to the Homo sapiens BLM gene, suggesting functional similarity [28].
  • In this study, we characterize one of the EDEM homologs from Homo sapiens, which we have termed EDEM2 (C20orf31) [29].

Analytical, diagnostic and therapeutic context of Humans


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  3. Arsenic counteracts human immunodeficiency virus type 1 restriction by various TRIM5 orthologues in a cell type-dependent manner. Sebastian, S., Sokolskaja, E., Luban, J. J. Virol. (2006) [Pubmed]
  4. Immune responses to DNA mismatch repair enzymes hMSH2 and hPMS1 in patients with pancreatic cancer, dermatomyositis and polymyositis. Okada, T., Noji, S., Goto, Y., Iwata, T., Fujita, T., Okada, T., Matsuzaki, Y., Kuwana, M., Hirakata, M., Horii, A., Matsuno, S., Sunamura, M., Kawakami, Y. Int. J. Cancer (2005) [Pubmed]
  5. Identification and expression of the Saccharomyces cerevisiae cytoplasmic tryptophanyl-tRNA synthetase gene. John, T.R., Ghosh, M., Johnson, J.D. Yeast (1997) [Pubmed]
  6. The genetic legacy of Paleolithic Homo sapiens sapiens in extant Europeans: a Y chromosome perspective. Semino, O., Passarino, G., Oefner, P.J., Lin, A.A., Arbuzova, S., Beckman, L.E., De Benedictis, G., Francalacci, P., Kouvatsi, A., Limborska, S., Marcikiae, M., Mika, A., Mika, B., Primorac, D., Santachiara-Benerecetti, A.S., Cavalli-Sforza, L.L., Underhill, P.A. Science (2000) [Pubmed]
  7. African Homo erectus: old radiometric ages and young Oldowan assemblages in the Middle Awash Valley, Ethiopia. Clark, J.D., de Heinzelin, J., Schick, K.D., Hart, W.K., White, T.D., WoldeGabriel, G., Walter, R.C., Suwa, G., Asfaw, B., Vrba, E. Science (1994) [Pubmed]
  8. Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics. Lee, M.D., She, Y., Soskis, M.J., Borella, C.P., Gardner, J.R., Hayes, P.A., Dy, B.M., Heaney, M.L., Philips, M.R., Bornmann, W.G., Sirotnak, F.M., Scheinberg, D.A. J. Clin. Invest. (2004) [Pubmed]
  9. RAP--a putative RNA-binding domain. Lee, I., Hong, W. Trends Biochem. Sci. (2004) [Pubmed]
  10. The TIP GROWTH DEFECTIVE1 S-acyl transferase regulates plant cell growth in Arabidopsis. Hemsley, P.A., Kemp, A.C., Grierson, C.S. Plant Cell (2005) [Pubmed]
  11. Molecular cloning and nucleotide sequence of the protyrosinase gene, melO, from Aspergillus oryzae and expression of the gene in yeast cells. Fujita, Y., Uraga, Y., Ichisima, E. Biochim. Biophys. Acta (1995) [Pubmed]
  12. Identification of a retrovirus-like repetitive element in human DNA. Mager, D.L., Henthorn, P.S. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  13. Ectopic expression of cdc2/cdc28 kinase subunit Homo sapiens 1 uncouples cyclin B metabolism from the mitotic spindle cell cycle checkpoint. Hixon, M.L., Flores, A.I., Wagner, M.W., Gualberto, A. Mol. Cell. Biol. (1998) [Pubmed]
  14. A genome-wide survey of RS domain proteins. Boucher, L., Ouzounis, C.A., Enright, A.J., Blencowe, B.J. RNA (2001) [Pubmed]
  15. Cloning, genomic structure and chromosomal localization of the gene encoding mouse DNA helicase RECQL5beta. Ohhata, T., Araki, R., Fukumura, R., Kuroiwa, A., Matsuda, Y., Abe, M. Gene (2001) [Pubmed]
  16. SMN gene duplication and the emergence of the SMN2 gene occurred in distinct hominids: SMN2 is unique to Homo sapiens. Rochette, C.F., Gilbert, N., Simard, L.R. Hum. Genet. (2001) [Pubmed]
  17. Identifying metameric variation in extant hominoid and fossil hominid mandibular molars. Hlusko, L.J. Am. J. Phys. Anthropol. (2002) [Pubmed]
  18. Centrosomal kinases, HsAIRK1 and HsAIRK3, are overexpressed in primary colorectal cancers. Takahashi, T., Futamura, M., Yoshimi, N., Sano, J., Katada, M., Takagi, Y., Kimura, M., Yoshioka, T., Okano, Y., Saji, S. Jpn. J. Cancer Res. (2000) [Pubmed]
  19. A high inorganic phosphate diet perturbs brain growth, alters Akt-ERK signaling, and results in changes in cap-dependent translation. Jin, H., Hwang, S.K., Yu, K., Anderson, H.K., Lee, Y.S., Lee, K.H., Prats, A.C., Morello, D., Beck, G.R., Cho, M.H. Toxicol. Sci. (2006) [Pubmed]
  20. Participation of kin17 protein in replication factories and in other DNA transactions mediated by high molecular weight nuclear complexes. Biard, D.S., Miccoli, L., Despras, E., Harper, F., Pichard, E., Créminon, C., Angulo, J.F. Mol. Cancer Res. (2003) [Pubmed]
  21. Polymorphism, shared functions and convergent evolution of genes with sequences coding for polyalanine domains. Lavoie, H., Debeane, F., Trinh, Q.D., Turcotte, J.F., Corbeil-Girard, L.P., Dicaire, M.J., Saint-Denis, A., Pagé, M., Rouleau, G.A., Brais, B. Hum. Mol. Genet. (2003) [Pubmed]
  22. Tamoxifen down-regulates CD36 messenger RNA levels in normal and neoplastic human breast tissues. Silva, I.D., Salicioni, A.M., Russo, I.H., Higgy, N.A., Gebrim, L.H., Russo, J. Cancer Res. (1997) [Pubmed]
  23. Crystal structures of human glycerol 3-phosphate dehydrogenase 1 (GPD1). Ou, X., Ji, C., Han, X., Zhao, X., Li, X., Mao, Y., Wong, L.L., Bartlam, M., Rao, Z. J. Mol. Biol. (2006) [Pubmed]
  24. Five novel immunogenic antigens in meningioma: cloning, expression analysis, and chromosomal mapping. Comtesse, N., Heckel, D., Rácz, A., Brass, N., Glass, B., Meese, E. Clin. Cancer Res. (1999) [Pubmed]
  25. Human and yeast Rad52 proteins promote DNA strand exchange. Bi, B., Rybalchenko, N., Golub, E.I., Radding, C.M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  26. Studies of the properties of human origin recognition complex and its Walker A motif mutants. Giordano-Coltart, J., Ying, C.Y., Gautier, J., Hurwitz, J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  27. Characterization and expression of mammalian cyclin b3, a prepachytene meiotic cyclin. Nguyen, T.B., Manova, K., Capodieci, P., Lindon, C., Bottega, S., Wang, X.Y., Refik-Rogers, J., Pines, J., Wolgemuth, D.J., Koff, A. J. Biol. Chem. (2002) [Pubmed]
  28. Evolution of the RECQ family of helicases: A drosophila homolog, Dmblm, is similar to the human bloom syndrome gene. Kusano, K., Berres, M.E., Engels, W.R. Genetics (1999) [Pubmed]
  29. Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins. Mast, S.W., Diekman, K., Karaveg, K., Davis, A., Sifers, R.N., Moremen, K.W. Glycobiology (2005) [Pubmed]
  30. Mast cells: a unique source of renin. Silver, R.B., Reid, A.C., Mackins, C.J., Askwith, T., Schaefer, U., Herzlinger, D., Levi, R. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  31. Polymorphism in mitochondrial DNA of humans as revealed by restriction endonuclease analysis. Brown, W.M. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  32. Genetic alterations of hepatocellular carcinoma by random amplified polymorphic DNA analysis and cloning sequencing of tumor differential DNA fragment. Xian, Z.H., Cong, W.M., Zhang, S.H., Wu, M.C. World J. Gastroenterol. (2005) [Pubmed]
  33. Comparative RB1 gene mapping in Homo sapiens, Pithecia pithecia, Macaca sylvana, and Cercopithecus aethiops tantalus. Tihy, F., Lemieux, N., Lombard, M., Dutrillaux, B. Cytogenet. Cell Genet. (1996) [Pubmed]
  34. Molecular cloning and characterization of SGT1.2, a novel splice variant of Homo sapiens SGT1. Zou, X., Ji, C., Wang, L., Wu, M., Zheng, H., Xu, J., Jin, F., Gu, S., Ying, K., Xie, Y., Mao, Y. DNA Seq. (2004) [Pubmed]
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