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Gene Review:

DNCI1 - dynein, cytoplasmic 1, intermediate chain 1

Macaca mulatta

Payne, C. et al., Mohamed, M.K. et al.

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High impact information on DNCI1

Both parthenogenetic activation in oocytes and microtubule depolymerization in zygotes significantly reduce the localization of dynein to the female pronucleus but do not inhibit the pronuclear association of dynactin [1].
Preferentially localized dynein and perinuclear dynactin associate with nuclear pore complex proteins to mediate genomic union during mammalian fertilization [1].
Transfection of antibodies against dynein and dynactin block female pronuclear migration in zygotes [1].

Associations of DNCI1 with chemical compounds

Methyl mercury interference with the dynein/microtubule sliding assembly now seems to us to be a more tenable hypothesis [2].

References

Preferentially localized dynein and perinuclear dynactin associate with nuclear pore complex proteins to mediate genomic union during mammalian fertilization. Payne, C., Rawe, V., Ramalho-Santos, J., Simerly, C., Schatten, G. J. Cell. Sci. (2003) [Pubmed]
Effects of methyl mercury on sperm oxygen consumption. Mohamed, M.K., Evans, T.C., Mottet, N.K., Burbacher, T.M. Acta pharmacologica et toxicologica. (1986) [Pubmed]

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