High impact information on Dync1i1

• The Tctex-1 binding site on DIC was mapped to a 19-residue fragment immediately following the second alternative splicing site of DIC [1].
• Cytoplasmic dynein intermediate chain and heavy chain are dependent upon each other for microtubule end localization in Aspergillus nidulans [2].
• We report here the identification of the human homologue of cytoplasmic dynein intermediate chain 1 gene (DNCI1) located on human chromosome 7q21.3-q22 [3].
• In neurons with stationary morphology, NudC is distributed throughout the soma and colocalizes with CDIC and tubulin in neurites as well as at the MTOC [4].

Biological context of Dync1i1

• At the subcellular level, NudC, CDIC, and p150 dynactin colocalize to the interphase microtubule array and the MTOC in fibroblasts [4].

Physical interactions of Dync1i1

• We further demonstrated that Tctex-1 binds directly to the intermediate chain (DIC) of dynein [1].

Other interactions of Dync1i1

• Structure of Tctex-1 and its interaction with cytoplasmic dynein intermediate chain [1].

Analytical, diagnostic and therapeutic context of Dync1i1

• Dissection of the cytoplasmic dynein complex revealed that Tctex1, an Mr 8000 LC dimer, and IC74 associate to define a basal-located intermediate chain/light chain complex analogous to that found in flagellar outer arm dynein [5].

References