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Gene Review

Dync1i1  -  dynein cytoplasmic 1 intermediate chain 1

Mus musculus

Synonyms: Cytoplasmic dynein 1 intermediate chain 1, Cytoplasmic dynein intermediate chain 1, DH IC-1, DHIC-1, DIC, ...
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High impact information on Dync1i1


Biological context of Dync1i1


Physical interactions of Dync1i1

  • We further demonstrated that Tctex-1 binds directly to the intermediate chain (DIC) of dynein [1].

Other interactions of Dync1i1


Analytical, diagnostic and therapeutic context of Dync1i1

  • Dissection of the cytoplasmic dynein complex revealed that Tctex1, an Mr 8000 LC dimer, and IC74 associate to define a basal-located intermediate chain/light chain complex analogous to that found in flagellar outer arm dynein [5].


  1. Structure of Tctex-1 and its interaction with cytoplasmic dynein intermediate chain. Mok, Y.K., Lo, K.W., Zhang, M. J. Biol. Chem. (2001) [Pubmed]
  2. Cytoplasmic dynein intermediate chain and heavy chain are dependent upon each other for microtubule end localization in Aspergillus nidulans. Zhang, J., Han, G., Xiang, X. Mol. Microbiol. (2002) [Pubmed]
  3. Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human. Crackower, M.A., Sinasac, D.S., Xia, J., Motoyama, J., Prochazka, M., Rommens, J.M., Scherer, S.W., Tsui, L.C. Genomics (1999) [Pubmed]
  4. NudC associates with Lis1 and the dynein motor at the leading pole of neurons. Aumais, J.P., Tunstead, J.R., McNeil, R.S., Schaar, B.T., McConnell, S.K., Lin, S.H., Clark, G.D., Yu-Lee, L.Y. J. Neurosci. (2001) [Pubmed]
  5. Cytoplasmic dynein contains a family of differentially expressed light chains. King, S.M., Barbarese, E., Dillman, J.F., Benashski, S.E., Do, K.T., Patel-King, R.S., Pfister, K.K. Biochemistry (1998) [Pubmed]
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