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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PDP2  -  pyruvate dehyrogenase phosphatase...

Homo sapiens

Synonyms: KIAA1348, PDP 2, PDPC 2, PPM2C2, Pyruvate dehydrogenase phosphatase catalytic subunit 2
 
 
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High impact information on PDP2

  • Both isoenzymes are expressed in mitochondria from 3T3-L1 adipocytes, but the level of expression of PDP2 is considerably higher [1].
  • Both isoenzymes of phosphatase (PDP1 and PDP2) readily reactivate the complex phosphorylated by PDK2 [2].
 

Biological context of PDP2

  • However, the nature of the human mutation (loss of a single amino acid altering PDP1 activity) made it impossible to discern the role of the second phosphatase isoform, PDP2, in the deficient phenotype [3].

References

  1. Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino acid sequences, expression, and regulation. Huang, B., Gudi, R., Wu, P., Harris, R.A., Hamilton, J., Popov, K.M. J. Biol. Chem. (1998) [Pubmed]
  2. Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites. Kolobova, E., Tuganova, A., Boulatnikov, I., Popov, K.M. Biochem. J. (2001) [Pubmed]
  3. Identification of a canine model of pyruvate dehydrogenase phosphatase 1 deficiency. Cameron, J.M., Maj, M.C., Levandovskiy, V., Mackay, N., Shelton, G.D., Robinson, B.H. Mol. Genet. Metab. (2007) [Pubmed]
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