Gene Review:
PDK2 - pyruvate dehydrogenase kinase, isozyme 2
Homo sapiens
Synonyms:
PDH kinase 2, PDHK2, PDKII, Pyruvate dehydrogenase kinase isoform 2
- Insulin downregulates pyruvate dehydrogenase kinase (PDK) mRNA: potential mechanism contributing to increased lipid oxidation in insulin-resistant subjects. Majer, M., Popov, K.M., Harris, R.A., Bogardus, C., Prochazka, M. Mol. Genet. Metab. (1998)
- Formation of functional heterodimers by isozymes 1 and 2 of pyruvate dehydrogenase kinase. Boulatnikov, I., Popov, K.M. Biochim. Biophys. Acta (2003)
- A translation frameshift mutation induced by a cytosine insertion in the polycystic kidney disease 2 gene (PDK2). Xenophontos, S., Constantinides, R., Hayashi, T., Mochizuki, T., Somlo, S., Pierides, A., Deltas, C.C. Hum. Mol. Genet. (1997)
- SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity. Jacinto, E., Facchinetti, V., Liu, D., Soto, N., Wei, S., Jung, S.Y., Huang, Q., Qin, J., Su, B. Cell (2006)
- The akt kinase: molecular determinants of oncogenicity. Aoki, M., Batista, O., Bellacosa, A., Tsichlis, P., Vogt, P.K. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Estrogen-related Receptors Stimulate Pyruvate Dehydrogenase Kinase Isoform 4 Gene Expression. Zhang, Y., Ma, K., Sadana, P., Chowdhury, F., Gaillard, S., Wang, F., McDonnell, D.P., Unterman, T.G., Elam, M.B., Park, E.A. J. Biol. Chem. (2006)
- Facilitated interaction between the pyruvate dehydrogenase kinase isoform 2 and the dihydrolipoyl acetyltransferase. Hiromasa, Y., Roche, T.E. J. Biol. Chem. (2003)
- Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase. Korotchkina, L.G., Patel, M.S. J. Biol. Chem. (2001)
- Diversity of the pyruvate dehydrogenase kinase gene family in humans. Gudi, R., Bowker-Kinley, M.M., Kedishvili, N.Y., Zhao, Y., Popov, K.M. J. Biol. Chem. (1995)
- High-fat/low-carbohydrate diet reduces insulin-stimulated carbohydrate oxidation but stimulates nonoxidative glucose disposal in humans: an important role for skeletal muscle pyruvate dehydrogenase kinase 4. Chokkalingam, K., Jewell, K., Norton, L., Littlewood, J., van Loon, L.J., Mansell, P., Macdonald, I.A., Tsintzas, K. J. Clin. Endocrinol. Metab. (2007)
- Pyruvate dehydrogenase kinase isoform 2 activity limited and further inhibited by slowing down the rate of dissociation of ADP. Bao, H., Kasten, S.A., Yan, X., Roche, T.E. Biochemistry (2004)
- Phosphoinositide-dependent kinase-2 is a distinct protein kinase enriched in a novel cytoskeletal fraction associated with adipocyte plasma membranes. Hresko, R.C., Murata, H., Mueckler, M. J. Biol. Chem. (2003)
- PI3K-Akt pathway: its functions and alterations in human cancer. Osaki, M., Oshimura, M., Ito, H. Apoptosis (2004)
- Marked differences between two isoforms of human pyruvate dehydrogenase kinase. Baker, J.C., Yan, X., Peng, T., Kasten, S., Roche, T.E. J. Biol. Chem. (2000)
- Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites. Kolobova, E., Tuganova, A., Boulatnikov, I., Popov, K.M. Biochem. J. (2001)
- Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells. Abbot, E.L., McCormack, J.G., Reynet, C., Hassall, D.G., Buchan, K.W., Yeaman, S.J. FEBS J. (2005)
- Kinase phosphorylation: Keeping it all in the family. Peterson, R.T., Schreiber, S.L. Curr. Biol. (1999)
- Pyruvate dehydrogenase kinase isoform 2 activity stimulated by speeding up the rate of dissociation of ADP. Bao, H., Kasten, S.A., Yan, X., Hiromasa, Y., Roche, T.E. Biochemistry (2004)
- Polycystic kidney disease: <<30 ans après>>. Grünfeld, J.P., Chauveau, D., Joly, D., Fonck, C., Oualim, Z. J. Nephrol. (1999)
- PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2. Balendran, A., Casamayor, A., Deak, M., Paterson, A., Gaffney, P., Currie, R., Downes, C.P., Alessi, D.R. Curr. Biol. (1999)
- Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2. Kobayashi, T., Cohen, P. Biochem. J. (1999)
- Targeted upregulation of pyruvate dehydrogenase kinase (PDK)-4 in slow-twitch skeletal muscle underlies the stable modification of the regulatory characteristics of PDK induced by high-fat feeding. Holness, M.J., Kraus, A., Harris, R.A., Sugden, M.C. Diabetes (2000)
- Human skeletal muscle PDH kinase activity and isoform expression during a 3-day high-fat/low-carbohydrate diet. Peters, S.J., Harris, R.A., Wu, P., Pehleman, T.L., Heigenhauser, G.J., Spriet, L.L. Am. J. Physiol. Endocrinol. Metab. (2001)
- Gene expressions and copy numbers associated with metastatic phenotypes of uterine cervical cancer. Lyng, H., Br??vig, R.S., Svendsrud, D.H., Holm, R., Kaalhus, O., Knutstad, K., Oksefjell, H., Sundf??r, K., Kristensen, G.B., Stokke, T. BMC Genomics (2006)
- Oxysterol-binding protein-related protein (ORP) 9 is a PDK-2 substrate and regulates Akt phosphorylation. Lessmann, E., Ngo, M., Leitges, M., Minguet, S., Ridgway, N.D., Huber, M. Cell. Signal. (2007)