High impact information on NLGN2

• The postsynaptic adhesion molecules neuroligin-1, neuroligin-2, and SynCAM1 provide target-derived signals leading to the assembly of presynaptic terminals [1].
• Gene expression analysis of the pro-oestrous-stage rat uterus reveals neuroligin 2 as a novel steroid-regulated gene [2].
• In addition, neuroligin 2 mRNA levels were increased by both 17beta-oestradiol (E(2)) and P(4), although P(4) administration upregulated gene expression to a greater extent than injection of E(2) [2].

Anatomical context of NLGN2

• One of the most interesting findings of the present study is the unexpected and marked expression of the neuroligin 2 gene in the rat uterus [2].

Analytical, diagnostic and therapeutic context of NLGN2

• According to Northern blot analysis, neuroligin 2 gene expression was higher during the pro-oestrus and metoestrus stages than during the oestrus and dioestrus stages of the oestrous cycle [2].

References