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Gene Review

USP28  -  ubiquitin specific peptidase 28

Homo sapiens

Synonyms: Deubiquitinating enzyme 28, KIAA1515, Ubiquitin carboxyl-terminal hydrolase 28, Ubiquitin thioesterase 28, Ubiquitin-specific-processing protease 28
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High impact information on USP28

  • In this cell line, both USP28 and Chk2 are required for DNA-damage-induced apoptosis, and they accomplish this in part through regulation of the p53 induction of proapoptotic genes like PUMA [1].
  • Using a human cell line that faithfully recapitulated the Chk2-p53-PUMA pathway, we show that USP28 is required to stabilize Chk2 and 53BP1 in response to DNA damage [1].
  • We tabulate these criteria for the Mark II eight-stage Andersen cascade impactor and the Next Generation Pharmaceutical Impactor in a manner similar to the tables of critical impactor dimensions published in EP Supplement 5.1 and in USP 28 [2].
  • Characterization of alternatively spliced products and tissue-specific isoforms of USP28 and USP25 [3].
  • RESULTS: Database homology searches at the DNA and protein levels and cDNA library screenings led to the identification of a new UBP member in the human genome, named USP28, at 11q23 [3].


  1. A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response. Zhang, D., Zaugg, K., Mak, T.W., Elledge, S.J. Cell (2006) [Pubmed]
  2. Relationship of stage mensuration data to the performance of new and used cascade impactors. Roberts, D.L., Romay, F.J. Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine. (2005) [Pubmed]
  3. Characterization of alternatively spliced products and tissue-specific isoforms of USP28 and USP25. Valero, R., Bayés, M., Francisca Sánchez-Font, M., González-Angulo, O., Gonzàlez-Duarte, R., Marfany, G. Genome Biol. (2001) [Pubmed]
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