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Gene Review

USP25  -  ubiquitin specific peptidase 25

Homo sapiens

Synonyms: Deubiquitinating enzyme 25, USP on chromosome 21, USP21, Ubiquitin carboxyl-terminal hydrolase 25, Ubiquitin thioesterase 25, ...
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Disease relevance of USP25


High impact information on USP25

  • The USP25 gene, located at 21q11.2, encodes three protein isoforms produced by alternative splicing [2].
  • While two of the isoforms are expressed nearly ubiquituously, the expression of the longer USP25 isoform (USP25m) is restricted to muscular tissues and is upregulated during myogenesis [2].
  • USP25 is made up of 25 exons and encodes a 1087-aa protein [1].
  • All analytical values fall within the labeled amount of 90-110% for betamethasone and prednisolone, and of the labeled amount of 92.5-107.5% for 6alpha-methylprednisolone, as required by the United State Pharmacopeia 25 (USP 25) [3].
  • Characterization of alternatively spliced products and tissue-specific isoforms of USP28 and USP25 [4].

Biological context of USP25


Anatomical context of USP25

  • We have lately reported the characterization of human USP25, a specific-ubiquitin protease gene at 21q11.2, with a specific pattern of expression in murine fetal brains and adult testis [4].

Analytical, diagnostic and therapeutic context of USP25


  1. USP25, a novel gene encoding a deubiquitinating enzyme, is located in the gene-poor region 21q11.2. Valero, R., Marfany, G., González-Angulo, O., González-González, G., Puelles, L., Gonzàlez-Duarte, R. Genomics (1999) [Pubmed]
  2. The ubiquitin-specific protease USP25 interacts with three sarcomeric proteins. Bosch-Comas, A., Lindsten, K., Gonzàlez-Duarte, R., Masucci, M.G., Marfany, G. Cell. Mol. Life Sci. (2006) [Pubmed]
  3. Micellar electrokinetic chromatography for simultaneous determination of six corticosteroids in commercial pharmaceuticals. Kuo, C.Y., Wu, S.M. Journal of separation science. (2005) [Pubmed]
  4. Characterization of alternatively spliced products and tissue-specific isoforms of USP28 and USP25. Valero, R., Bayés, M., Francisca Sánchez-Font, M., González-Angulo, O., Gonzàlez-Duarte, R., Marfany, G. Genome Biol. (2001) [Pubmed]
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