Disease relevance of USP25

• An increase in USP25 gene dosage in Down syndrome patients could seriously disturb the balance between ubiquitinated and deubiquitinated substrates [1].

High impact information on USP25

• The USP25 gene, located at 21q11.2, encodes three protein isoforms produced by alternative splicing [2].
• While two of the isoforms are expressed nearly ubiquituously, the expression of the longer USP25 isoform (USP25m) is restricted to muscular tissues and is upregulated during myogenesis [2].
• USP25 is made up of 25 exons and encodes a 1087-aa protein [1].
• All analytical values fall within the labeled amount of 90-110% for betamethasone and prednisolone, and of the labeled amount of 92.5-107.5% for 6alpha-methylprednisolone, as required by the United State Pharmacopeia 25 (USP 25) [3].
• Characterization of alternatively spliced products and tissue-specific isoforms of USP28 and USP25 [4].

Biological context of USP25

• The overexpression of USP25 in Down syndrome fetal brains supports the gene-dosage effects suggested for other UBP members related to aneuploidy syndromes [4].

Anatomical context of USP25

• We have lately reported the characterization of human USP25, a specific-ubiquitin protease gene at 21q11.2, with a specific pattern of expression in murine fetal brains and adult testis [4].

Analytical, diagnostic and therapeutic context of USP25

• Concerning function, USP25 overexpression in Down syndrome fetal brains was shown by real-time PCR [4].

References