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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Tbc1d1  -  TBC1 domain family, member 1

Mus musculus

Synonyms: 1110062G02Rik, AI385682, AW555803, Kiaa1108, Nob1, ...
 
 
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Disease relevance of Tbc1d1

  • Influence of the mouse Bcg, Tbc-1 and xid genes on resistance and immune responses to tuberculosis infection and efficacy of bacille Calmette-Guérin (BCG) vaccination [1].
 

High impact information on Tbc1d1

  • Based on sequence similarity, pattern of expression and subcellular localization, Tbc1 may play a role in the cell cycle and differentiation of various tissues [2].
  • A novel cDNA, designated Tbc1, was identified that showed differential expression in the two mast cell lines [2].
  • Tbc1 is a nuclear protein and is expressed in highest levels in hematopoietic cells, testis and kidney [2].
  • We have studied the role of three mouse distinct non-H-2 genes (Bcg, Tbc-1, xid) in several phenomena of antituberculosis immunity and resistance [1].
 

Regulatory relationships of Tbc1d1

  • In the present study, we show in 3T3-L1 adipocytes that Tbc1d1 is only 1/20 as abundant as AS160, that knockdown of Tbc1d1 has no effect on insulin-stimulated GLUT4 translocation, and that overexpressed Tbc1d1 also inhibits GLUT4 translocation elicited by activated Akt expression [3].

References

  1. Influence of the mouse Bcg, Tbc-1 and xid genes on resistance and immune responses to tuberculosis infection and efficacy of bacille Calmette-Guérin (BCG) vaccination. Nikonenko, B.V., Apt, A.S., Mezhlumova, M.B., Avdienko, V.G., Yeremeev, V.V., Moroz, A.M. Clin. Exp. Immunol. (1996) [Pubmed]
  2. Molecular cloning of a cDNA with a novel domain present in the tre-2 oncogene and the yeast cell cycle regulators BUB2 and cdc16. Richardson, P.M., Zon, L.I. Oncogene (1995) [Pubmed]
  3. Inhibition of GLUT4 translocation by Tbc1d1, a Rab GTPase-activating protein abundant in skeletal muscle, is partially relieved by AMP-activated protein kinase activation. Chavez, J.A., Roach, W.G., Keller, S.R., Lane, W.S., Lienhard, G.E. J. Biol. Chem. (2008) [Pubmed]
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