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Gene Review

hey1  -  hes-related family bHLH transcription...

Danio rerio

Synonyms: Hairy/enhancer-of-split related with YRPW motif protein 1, SO:0000704, id:ibd1292, zgc:110572
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High impact information on hey1

  • In deltaD (dlD) deficient after-eight zebrafish mutants, the dynamic expression of hey1 in the PSM is impaired and completely lost in newly formed somitomeres [1].
  • Overexpression of dlD on the other hand results in the ectopic expression of hey1 in the axial mesoderm [1].
  • her7 and hey1, but not lunatic fringe show dynamic expression during somitogenesis in medaka (Oryzias latipes) [2].
  • Interestingly, medaka hey1 is also expressed in the dorsal aorta and the heart, two tissues where hey2, but not hey1, is expressed in zebrafish [2].


  1. Characterization of hey bHLH genes in teleost fish. Winkler, C., Elmasri, H., Klamt, B., Volff, J.N., Gessler, M. Dev. Genes Evol. (2003) [Pubmed]
  2. her7 and hey1, but not lunatic fringe show dynamic expression during somitogenesis in medaka (Oryzias latipes). Elmasri, H., Liedtke, D., Lücking, G., Volff, J.N., Gessler, M., Winkler, C. Gene Expr. Patterns (2004) [Pubmed]
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