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Disease relevance of Oryzias


Psychiatry related information on Oryzias


High impact information on Oryzias


Chemical compound and disease context of Oryzias


Biological context of Oryzias

  • Linkage mapping in medaka followed by comparative genomic analyses among fishes and humans located four CNP genes in separate medaka chromosomes corresponding to human chromosomes 1, 2, 12, and 17 [16].
  • Using an in situ screen on a cortical structure of the medaka fish brain, we identified the simplet gene (smp), which is homologous to the human FAM53B gene. smp was expressed in actively proliferating cells of the CNS throughout embryogenesis [17].
  • In this study, we first show that this conserved sequence motif is also physically linked to the Shh coding sequence in a teleost fish, the medaka, by homology search of a newly available genomic sequence database [18].
  • The deduced amino acid sequence shows moderate levels of identity to medaka HCE1 (52.5%), medaka LCE (50.7%), crayfish astacin (33.2%), murine meprin-alpha (34%), and murine meprin-beta (33.5%), all members of the astacin family of zinc endopeptidases [19].
  • Now, a gene has been isolated from the Y chromosome of the teleost fish medaka that is functionally comparable to the mammalian testis-determining gene, Sry [20].

Anatomical context of Oryzias


Associations of Oryzias with chemical compounds


Gene context of Oryzias

  • Gain-of-function studies in medaka show a clear synergistic activity between SIX3/SIX6 and TLE1, which, on its own, can expand the eye field [29].
  • Here we report the isolation of Ol-eng2, a medaka fish (Oryzias latipes) engrailed gene [30].
  • Rh50 genes of African clawed frog and Japanese medaka fish formed a cluster with mammalian Rh50 genes [31].
  • Sequence analysis indicates that this protein is orthologous to GRK7 recently cloned from O. latipes, the medaka fish [32].
  • The goldfish ER had high overall sequence identity when compared to other vertebrate ER sequences: eel (64%), human beta subtype (59%), human alpha subtype (46%), medaka (46%), and rainbow trout (47%) [33].

Analytical, diagnostic and therapeutic context of Oryzias


  1. Histologic and electron microscopy observations on diethylnitrosamine-induced hepatomas in small aquarium fish (Oryzias latipes). Ishikawa, T., Shimamine, T., Takayama, S. J. Natl. Cancer Inst. (1975) [Pubmed]
  2. Induction of hepatic tumors in a teleost (Oryzias latipes) after treatment with methylazoxymethanol acetate: brief communication. Aoki, K., Matsudaira, H. J. Natl. Cancer Inst. (1977) [Pubmed]
  3. Fish mesonephric model of polycystic kidney disease in medaka (Oryzias latipes) pc mutant. Mochizuki, E., Fukuta, K., Tada, T., Harada, T., Watanabe, N., Matsuo, S., Hashimoto, H., Ozato, K., Wakamatsu, Y. Kidney Int. (2005) [Pubmed]
  4. A mutation in the gene for delta-aminolevulinic acid dehydratase (ALAD) causes hypochromic anemia in the medaka, Oryzias latipes. Sakamoto, D., Kudo, H., Inohaya, K., Yokoi, H., Narita, T., Naruse, K., Mitani, H., Araki, K., Shima, A., Ishikawa, Y., Imai, Y., Kudo, A. Mech. Dev. (2004) [Pubmed]
  5. The oculocutaneous albinism type IV gene Matp is a new marker of pigment cell precursors during mouse embryonic development. Baxter, L.L., Pavan, W.J. Mech. Dev. (2002) [Pubmed]
  6. Mechanism of Ca2+ release in medaka eggs microinjected with inositol 1,4,5-trisphosphate and Ca2+. Iwamatsu, T., Yoshimoto, Y., Hiramoto, Y. Dev. Biol. (1988) [Pubmed]
  7. Mutations in the gene encoding B, a novel transporter protein, reduce melanin content in medaka. Fukamachi, S., Shimada, A., Shima, A. Nat. Genet. (2001) [Pubmed]
  8. Six3 overexpression initiates the formation of ectopic retina. Loosli, F., Winkler, S., Wittbrodt, J. Genes Dev. (1999) [Pubmed]
  9. Intraocular neoplasms induced by methylazoxymethanol acetate in Japanese medaka (Oryzias latipes). Hawkins, W.E., Fournie, J.W., Overstreet, R.M., Walker, W.W. J. Natl. Cancer Inst. (1986) [Pubmed]
  10. Histochemistry of liver tumors induced by diethylnitrosamine and differential sex susceptibility to carcinogenesis in Oryzias latipes. Nakazawa, T., Hamaguchi, S., Kyono-Hamaguchi, Y. J. Natl. Cancer Inst. (1985) [Pubmed]
  11. Approaches for establishing predicted-no-effect concentrations for population-level ecological risk assessment in the context of chemical substances management. Lin, B.L., Tokai, A., Nakanishi, J. Environ. Sci. Technol. (2005) [Pubmed]
  12. Potential mechanisms of the enhancement of aldicarb toxicity to Japanese medaka, Oryzias latipes, at high salinity. El-Alfy, A., Schlenk, D. Toxicol. Appl. Pharmacol. (1998) [Pubmed]
  13. Increasing uptake and bioactivation with development positively modulate diazinon toxicity in early life stage medaka (Oryzias latipes). Hamm, J.T., Wilson, B.W., Hinton, D.E. Toxicol. Sci. (2001) [Pubmed]
  14. Susceptibility of male and female medaka (Oryzias latipes) fish to spontaneous and X-ray induced micronucleus formation in gill cells. Takai, A., Kagawa, N., Fujikawa, K. Mutat. Res. (2004) [Pubmed]
  15. Feminization of Japanese medaka (Oryzias latipes) exposed to 17beta-estradiol: formation of testis-ova and sex-transformation during early-ontogeny. Hirai, N., Nanba, A., Koshio, M., Kondo, T., Morita, M., Tatarazako, N. Aquat. Toxicol. (2006) [Pubmed]
  16. Four functionally distinct C-type natriuretic peptides found in fish reveal evolutionary history of the natriuretic peptide system. Inoue, K., Naruse, K., Yamagami, S., Mitani, H., Suzuki, N., Takei, Y. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  17. Medaka simplet (FAM53B) belongs to a family of novel vertebrate genes controlling cell proliferation. Thermes, V., Candal, E., Alunni, A., Serin, G., Bourrat, F., Joly, J.S. Development (2006) [Pubmed]
  18. Elimination of a long-range cis-regulatory module causes complete loss of limb-specific Shh expression and truncation of the mouse limb. Sagai, T., Hosoya, M., Mizushina, Y., Tamura, M., Shiroishi, T. Development (2005) [Pubmed]
  19. Purification and cloning of carp nephrosin, a secreted zinc endopeptidase of the astacin family. Hung, C.H., Huang, H.R., Huang, C.J., Huang, F.L., Chang, G.D. J. Biol. Chem. (1997) [Pubmed]
  20. Vertebrate sex determination: a new player in the field. Swain, A. Curr. Biol. (2002) [Pubmed]
  21. Structural studies of a novel type of pentaantennary large glycan unit in the fertilization-associated carbohydrate-rich glycopeptide isolated from the fertilized eggs of Oryzias latipes. Taguchi, T., Seko, A., Kitajima, K., Muto, Y., Inoue, S., Khoo, K.H., Morris, H.R., Dell, A., Inoue, Y. J. Biol. Chem. (1994) [Pubmed]
  22. Evasion of UVC-induced apoptosis by photorepair of cyclobutane pyrimidine dimers. Nishigaki, R., Mitani, H., Shima, A. Exp. Cell Res. (1998) [Pubmed]
  23. Forebrain gonadotropin-releasing hormone neuronal development: insights from transgenic medaka and the relevance to X-linked Kallmann syndrome. Okubo, K., Sakai, F., Lau, E.L., Yoshizaki, G., Takeuchi, Y., Naruse, K., Aida, K., Nagahama, Y. Endocrinology (2006) [Pubmed]
  24. Expression of proprotein convertase 2 mRNA in the ovarian follicles of the medaka, Oryzias latipes. Ogiwara, K., Shinohara, M., Takahashi, T. Gene (2004) [Pubmed]
  25. Activation of the mouse Oct4 promoter in medaka embryonic stem cells and its use for ablation of spontaneous differentiation. Hong, Y., Winkler, C., Liu, T., Chai, G., Schartl, M. Mech. Dev. (2004) [Pubmed]
  26. Induction of transplantable melanoma by treatment with N-methyl-N'-nitro-N-nitrosoguanidine in an inbred strain of the teleost Oryzias latipes. Hyodo-Taguchi, Y., Matsudaira, H. J. Natl. Cancer Inst. (1984) [Pubmed]
  27. Isolation and characterization of a novel type of sialoglycoproteins (hyosophorin) from the eggs of medaka, Oryzias latipes: nonapeptide with a large N-linked glycan chain as a tandem repeat unit. Kitajima, K., Inoue, S., Inoue, Y. Dev. Biol. (1989) [Pubmed]
  28. Patterns of gene expression during teleost embryogenesis: lactate dehydrogenase isozyme ontogeny in the medaka (Oryzias latipes). Philipp, D.P., Whitt, G.S. Dev. Biol. (1977) [Pubmed]
  29. Six3 and Six6 activity is modulated by members of the groucho family. López-Ríos, J., Tessmar, K., Loosli, F., Wittbrodt, J., Bovolenta, P. Development (2003) [Pubmed]
  30. The midbrain-hindbrain boundary genetic cascade is activated ectopically in the diencephalon in response to the widespread expression of one of its components, the medaka gene Ol-eng2. Ristoratore, F., Carl, M., Deschet, K., Richard-Parpaillon, L., Boujard, D., Wittbrodt, J., Chourrout, D., Bourrat, F., Joly, J.S. Development (1999) [Pubmed]
  31. Evolutionary history of the Rh blood group-related genes in vertebrates. Kitano, T., Saitou, N. Immunogenetics (2000) [Pubmed]
  32. The cloning of GRK7, a candidate cone opsin kinase, from cone- and rod-dominant mammalian retinas. Weiss, E.R., Raman, D., Shirakawa, S., Ducceschi, M.H., Bertram, P.T., Wong, F., Kraft, T.W., Osawa, S. Mol. Vis. (1998) [Pubmed]
  33. Molecular cloning of an estrogen receptor beta subtype from the goldfish, Carassius auratus. Tchoudakova, A., Pathak, S., Callard, G.V. Gen. Comp. Endocrinol. (1999) [Pubmed]
  34. The accumulation of manganese from the environmental medium by the egg of Oryzias latipes. Michibata, H., Hori, R. J. Cell. Physiol. (1979) [Pubmed]
  35. Molecular cloning and characterization of a new RGS protein of Medaka. Itoh, M., Nagatomo, K., Kubo, Y., Sugimoto, M., Saitoh, O. Gene (2005) [Pubmed]
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