Disease relevance of Oryzias

• Liver neoplasms were induced in medakas (Oryzias latipes) by the addition of diethylnitrosamine (DENA) to their aquarium water at levels of 15-135 ppm for 8 weeks [1].
• Liver neoplasms including trabecular hepatoma and cholangioma were induced in medakas (Oryzias latipes) by the addition of methylazoxymethanol acetate to their aquarium water at levels of 0.1-3 ppm for periods ranging from 1 to 120 days [2].
• Fish mesonephric model of polycystic kidney disease in medaka (Oryzias latipes) pc mutant [3].
• A mutation in the gene for delta-aminolevulinic acid dehydratase (ALAD) causes hypochromic anemia in the medaka, Oryzias latipes [4].
• Mutations in MATP result in pigmentation alterations in mice (underwhite, uw), in medaka (b-locus), and in man (Oculocutaneous Albinism Type 4, OCA4) (Nat. Genet. 28 (2001) 381; Am. J. Hum. Genet. 69 (2001) 981) [5].

Psychiatry related information on Oryzias

• The reaction time of Ca2+ release from cytoplasmic stores induced by microinjection of inositol 1,4,5-trisphosphate (IP3), calcium ionophore A23187, Ca2+, Sr2+, Ba2+, and cyclic guanosine 5'-monophosphate (cGMP) in Oryzias latipes eggs in Ca2+-free medium was measured by the luminescence of aequorin injected into the egg [6].

High impact information on Oryzias

• One of these, an orange-red variant, is a homozygote of a well-known and common allele, b, and has been bred for hundreds of years by the Japanese. Here, we report the first successful positional cloning of a medaka gene (AIM1): one that encodes a transporter that mediates melanin synthesis [7].
• Injected mouse Six3 RNA initiates ectopic expression of endogenous medaka Six3, uncovering a feedback control of Six3 expression [8].
• Intraocular neoplasms induced by methylazoxymethanol acetate in Japanese medaka (Oryzias latipes) [9].
• Intraocular neoplasms developed in the Japanese medaka, a small fish species, following a single brief exposure to methylazoxymethanol acetate [(MAM-Ac) CAS: 592-62-1] [9].
• Liver tumor nodules were induced by the administration of diethylnitrosamine [(DENA) CAS: 55-18-5; N-nitrosodiethylamine] to the fish, Oryzias latipes [10].

Chemical compound and disease context of Oryzias

• We illustrate two feasible approaches for establishing predicted-no-effect concentrations (PNECs)for PLERA through a case study of 4-nonylphenol (4-NP) using life-cycle toxicity data for medaka (Oryzias latipes) [11].
• Potential mechanisms of the enhancement of aldicarb toxicity to Japanese medaka, Oryzias latipes, at high salinity [12].
• Increasing uptake and bioactivation with development positively modulate diazinon toxicity in early life stage medaka (Oryzias latipes) [13].
• The frequency of micronucleated cells (MNCs) was measured in acridine-orange (AO) stained RNA-rich gill cells from male and female medaka (Oryzias latipes) fish of known body weight [14].
• Feminization of Japanese medaka (Oryzias latipes) exposed to 17beta-estradiol: formation of testis-ova and sex-transformation during early-ontogeny [15].

Biological context of Oryzias

• Linkage mapping in medaka followed by comparative genomic analyses among fishes and humans located four CNP genes in separate medaka chromosomes corresponding to human chromosomes 1, 2, 12, and 17 [16].
• Using an in situ screen on a cortical structure of the medaka fish brain, we identified the simplet gene (smp), which is homologous to the human FAM53B gene. smp was expressed in actively proliferating cells of the CNS throughout embryogenesis [17].
• In this study, we first show that this conserved sequence motif is also physically linked to the Shh coding sequence in a teleost fish, the medaka, by homology search of a newly available genomic sequence database [18].
• The deduced amino acid sequence shows moderate levels of identity to medaka HCE1 (52.5%), medaka LCE (50.7%), crayfish astacin (33.2%), murine meprin-alpha (34%), and murine meprin-beta (33.5%), all members of the astacin family of zinc endopeptidases [19].
• Now, a gene has been isolated from the Y chromosome of the teleost fish medaka that is functionally comparable to the mammalian testis-determining gene, Sry [20].

Anatomical context of Oryzias

• Structural studies of a novel type of pentaantennary large glycan unit in the fertilization-associated carbohydrate-rich glycopeptide isolated from the fertilized eggs of Oryzias latipes [21].
• OCP13, a Medaka cell line showing a high level expression of the gene for CPD photolyase, completely reversed pyrimidine dimers induced by 20 J/m2 UVC by 1 h of photorepair [22].
• In the present study, we generated transgenic medaka that expressed green fluorescent protein under the control of the gnrh1 and gnrh3 promoters for analyzing forebrain GnRH neuronal development [23].
• Expression of proprotein convertase 2 mRNA in the ovarian follicles of the medaka, Oryzias latipes [24].
• Activation of the mouse Oct4 promoter in medaka embryonic stem cells and its use for ablation of spontaneous differentiation [25].

Associations of Oryzias with chemical compounds

• Histochemistry of liver tumors induced by diethylnitrosamine and differential sex susceptibility to carcinogenesis in Oryzias latipes [10].
• Adult fish of two different inbred strains (HO4C and HB32C) of Oryzias latipes that were established in this laboratory were exposed for 2 hours to an aqueous solution of the carcinogen N-methyl-N'-nitro-N-nitrosoguanidine [(MNNG) CAS: 70-25-7; 1-methyl-3-nitro-1-nitrosoguanidine] at concentrations from 20 to 100 ppm [26].
• Isolation and characterization of a novel type of sialoglycoproteins (hyosophorin) from the eggs of medaka, Oryzias latipes: nonapeptide with a large N-linked glycan chain as a tandem repeat unit [27].
• Mechanism of Ca2+ release in medaka eggs microinjected with inositol 1,4,5-trisphosphate and Ca2+ [6].
• Patterns of gene expression during teleost embryogenesis: lactate dehydrogenase isozyme ontogeny in the medaka (Oryzias latipes) [28].

Gene context of Oryzias

• Gain-of-function studies in medaka show a clear synergistic activity between SIX3/SIX6 and TLE1, which, on its own, can expand the eye field [29].
• Here we report the isolation of Ol-eng2, a medaka fish (Oryzias latipes) engrailed gene [30].
• Rh50 genes of African clawed frog and Japanese medaka fish formed a cluster with mammalian Rh50 genes [31].
• Sequence analysis indicates that this protein is orthologous to GRK7 recently cloned from O. latipes, the medaka fish [32].
• The goldfish ER had high overall sequence identity when compared to other vertebrate ER sequences: eel (64%), human beta subtype (59%), human alpha subtype (46%), medaka (46%), and rainbow trout (47%) [33].

Analytical, diagnostic and therapeutic context of Oryzias

• Induction of hepatic tumors in a teleost (Oryzias latipes) after treatment with methylazoxymethanol acetate: brief communication [2].
• The manganese content of the egg and embryo of the Medaka, Oryzias latipes was determined by activation analysis [34].
• Molecular cloning and characterization of a new RGS protein of Medaka [35].
• RT-PCR analysis demonstrated that this Medaka RGS3-like protein (MeRGS3L) is mainly expressed in skin and heart [35].
• We identified eight genes of putative RGS proteins in skin of Medaka fish using PCR amplification with degenerate primers for the RGS domain of known RGS proteins [35].

References