Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

PTPRS - protein tyrosine phosphatase, receptor...

Homo sapiens

Synonyms: R-PTP-S, R-PTP-sigma, Receptor-type tyrosine-protein phosphatase S, Receptor-type tyrosine-protein phosphatase sigma

Alete, D.E. et al., Siu, R. et al., Wagner, J. et al., Endo, N. et al., Aricescu, A.R. et al.

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High impact information on PTPRS

Protein tyrosine phosphatase sigma (PTPsigma) belongs to the LAR family of receptor tyrosine phosphatases and was previously shown to negatively regulate axon growth [1].
Heparan sulfate proteoglycans are ligands for receptor protein tyrosine phosphatase sigma [2].
Human protein tyrosine phosphatase-sigma: alternative splicing and inhibition by bisphosphonates [3].
Physical mapping of receptor type protein tyrosine phosphatase sigma (PTPRS) to human chromosome 19p13.3 [4].
In this study, we have used affinity chromatography and tandem MS to identify nucleolin as a binding partner for receptor protein tyrosine phosphatase-sigma in skeletal muscle tissue [5].

Anatomical context of PTPRS

A potential extracellular ligand for vertebrate receptor protein tyrosine phosphatase-sigma has been previously localized in developing skeletal muscle [5].
Its expression pattern also overlaps with that of the receptor protein tyrosine phosphatase-sigma-binding partner previously localized in muscle, and nucleolin can also be found in retinal basement membranes [5].

References

N-cadherin is an in vivo substrate for protein tyrosine phosphatase sigma (PTPsigma) and participates in PTPsigma-mediated inhibition of axon growth. Siu, R., Fladd, C., Rotin, D. Mol. Cell. Biol. (2007) [Pubmed]
Heparan sulfate proteoglycans are ligands for receptor protein tyrosine phosphatase sigma. Aricescu, A.R., McKinnell, I.W., Halfter, W., Stoker, A.W. Mol. Cell. Biol. (2002) [Pubmed]
Human protein tyrosine phosphatase-sigma: alternative splicing and inhibition by bisphosphonates. Endo, N., Rutledge, S.J., Opas, E.E., Vogel, R., Rodan, G.A., Schmidt, A. J. Bone Miner. Res. (1996) [Pubmed]
Physical mapping of receptor type protein tyrosine phosphatase sigma (PTPRS) to human chromosome 19p13.3. Wagner, J., Gordon, L.A., Heng, H.H., Tremblay, M.L., Olsen, A.S. Genomics (1996) [Pubmed]
Cell surface nucleolin on developing muscle is a potential ligand for the axonal receptor protein tyrosine phosphatase-sigma. Alete, D.E., Weeks, M.E., Hovanession, A.G., Hawadle, M., Stoker, A.W. FEBS J. (2006) [Pubmed]

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