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Gene Review

Ptprs  -  protein tyrosine phosphatase, receptor...

Mus musculus

Synonyms: AL022616, PTP, PTP-NU3, PTPNU-3, PTPsigma, ...
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Disease relevance of Ptprs

  • By approximately three weeks of age, most remaining Ptprs-/- mice died from a wasting syndrome with atrophic intestinal villi [1].
  • Since low dose injection of growth hormone (GH) normalized the response to exogenous insulin in RPTPsigma-/- mice, we propose that the insulin hypersensitivity observed in RPTPsigma-/- mice is secondary to their neuroendocrine dysplasia and GH/IGF-1 deficiency [2].
  • Dorsal root ganglion (DRG) neurons, which highly express endogenous N-cadherin and PTPsigma, exhibited a faster growth rate in the knockout mice than in the sibling controls when grown on laminin or N-cadherin substrata [3].

Psychiatry related information on Ptprs

  • The surviving Ptprs-/- mice demonstrated stunted growth, developmental delays and severe neurological defects including spastic movements, tremor, ataxic gait, abnormal limb flexion and defective proprioception [1].

High impact information on Ptprs

  • Moreover, peripheral nerve electrophysiological analysis revealed slower conduction velocity in Ptprs-/- mice relative to wild-type or heterozygous animals, associated with an increased proportion of slowly conducting, small-diameter myelinated fibres and relative hypomyelination [1].
  • Histopathology of brain sections revealed reduction and hypocellularity of the posterior pituitary of Ptprs-/- mice, as well as a reduction of approximately 50-75% in the number of choline acetyl transferase-positive cells in the forebrain [1].
  • Neuronal defects and posterior pituitary hypoplasia in mice lacking the receptor tyrosine phosphatase PTPsigma [1].
  • On the basis of its expression and homology with the Drosophila melanogasterorthologues DPTP99 and DPTP100A (refs 5,6), which have roles in the targeting of axonal growth cones, we hypothesized that PTP-sigma may also have a modulating function in cell-cell interactions, as well as in axon guidance during mammalian embryogenesis [4].
  • We have discovered that a member of the dual-specific protein tyrosine phosphatase (DS-PTP) family, PTPMT1 (PTP localized to the Mitochondrion 1) resides nearly exclusively in mitochondria [5].

Biological context of Ptprs


Anatomical context of Ptprs


Associations of Ptprs with chemical compounds


Other interactions of Ptprs


Analytical, diagnostic and therapeutic context of Ptprs


  1. Neuronal defects and posterior pituitary hypoplasia in mice lacking the receptor tyrosine phosphatase PTPsigma. Wallace, M.J., Batt, J., Fladd, C.A., Henderson, J.T., Skarnes, W., Rotin, D. Nat. Genet. (1999) [Pubmed]
  2. Altered glucose homeostasis in mice lacking the receptor protein tyrosine phosphatase sigma. Chagnon, M.J., Elchebly, M., Uetani, N., Dombrowski, L., Cheng, A., Mooney, R.A., Marette, A., Tremblay, M.L. Can. J. Physiol. Pharmacol. (2006) [Pubmed]
  3. N-cadherin is an in vivo substrate for protein tyrosine phosphatase sigma (PTPsigma) and participates in PTPsigma-mediated inhibition of axon growth. Siu, R., Fladd, C., Rotin, D. Mol. Cell. Biol. (2007) [Pubmed]
  4. Neuroendocrine dysplasia in mice lacking protein tyrosine phosphatase sigma. Elchebly, M., Wagner, J., Kennedy, T.E., Lanctôt, C., Michaliszyn, E., Itié, A., Drouin, J., Tremblay, M.L. Nat. Genet. (1999) [Pubmed]
  5. Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells. Pagliarini, D.J., Wiley, S.E., Kimple, M.E., Dixon, J.R., Kelly, P., Worby, C.A., Casey, P.J., Dixon, J.E. Mol. Cell (2005) [Pubmed]
  6. Developmental expression of the cell adhesion molecule-like protein tyrosine phosphatases LAR, RPTPdelta and RPTPsigma in the mouse. Schaapveld, R.Q., Schepens, J.T., Bächner, D., Attema, J., Wieringa, B., Jap, P.H., Hendriks, W.J. Mech. Dev. (1998) [Pubmed]
  7. Neural stem cells from protein tyrosine phosphatase sigma knockout mice generate an altered neuronal phenotype in culture. Kirkham, D.L., Pacey, L.K., Axford, M.M., Siu, R., Rotin, D., Doering, L.C. BMC neuroscience [electronic resource]. (2006) [Pubmed]
  8. A novel receptor tyrosine phosphatase-sigma that is highly expressed in the nervous system. Yan, H., Grossman, A., Wang, H., D'Eustachio, P., Mossie, K., Musacchio, J.M., Silvennoinen, O., Schlessinger, J. J. Biol. Chem. (1993) [Pubmed]
  9. Mammalian motoneuron axon targeting requires receptor protein tyrosine phosphatases sigma and delta. Uetani, N., Chagnon, M.J., Kennedy, T.E., Iwakura, Y., Tremblay, M.L. J. Neurosci. (2006) [Pubmed]
  10. Receptor protein tyrosine phosphatase sigma inhibits axonal regeneration and the rate of axon extension. Thompson, K.M., Uetani, N., Manitt, C., Elchebly, M., Tremblay, M.L., Kennedy, T.E. Mol. Cell. Neurosci. (2003) [Pubmed]
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