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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

MYL7  -  myosin, light chain 7, regulatory

Homo sapiens

Synonyms: MLC-2a, MLC2a, MYL2A, MYLC2A, Myosin light chain 2a, ...
 
 
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High impact information on MYL7

  • A dramatic decrease in expression of mRNAs encoding alpha-actin, MLC2a and MLC2v was observed in R58QMLC2vGFP EBs [1].
  • Key role of myosin light chain (MLC) kinase-mediated MLC2a phosphorylation in the alpha 1-adrenergic positive inotropic effect in human atrium [2].
 

Associations of MYL7 with chemical compounds

  • RESULTS: The alpha(1)-agonist phenylephrine (PE; 0.3-100 microM) exerted a concentration-dependent, monophasic, sustained positive inotropic effect (86% above basal) that was accompanied by an 80% increase in MLC2a phosphorylation [2].
 

Analytical, diagnostic and therapeutic context of MYL7

References

  1. Fine-tuning in Ca2+ homeostasis underlies progression of cardiomyopathy in myocytes derived from genetically modified embryonic stem cells. Grey, C., Méry, A., Pucéat, M. Hum. Mol. Genet. (2005) [Pubmed]
  2. Key role of myosin light chain (MLC) kinase-mediated MLC2a phosphorylation in the alpha 1-adrenergic positive inotropic effect in human atrium. Grimm, M., Haas, P., Willipinski-Stapelfeldt, B., Zimmermann, W.H., Rau, T., Pantel, K., Weyand, M., Eschenhagen, T. Cardiovasc. Res. (2005) [Pubmed]
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