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Gene Review:

SNX6 - sorting nexin 6

Homo sapiens

Synonyms: MSTP010, Sorting nexin-6, TFAF2, TRAF4-associated factor 2

Wassmer, T. et al., Parks, W.T. et al., Yoon, T. et al., Kamnasaran, D. et al.

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High impact information on SNX6

Of the type II receptors, SNX6 was found to interact strongly with ActRIIB and more moderately with wild type and kinase-defective mutants of TbetaRII [1].
Conversely, SNX6 behaved similarly to the other SNX proteins in its interactions with receptor tyrosine kinases [1].
Using this screen, we identified two proteins, SNX5 and SNX6, that, when suppressed, induced a phenotype similar to that observed upon suppression of known retromer components [2].
Such data suggest that SNX1 and SNX6 exist in a stable, endosomally associated complex that is required for retromer-mediated retrieval of the cation-independent mannose-6-phosphate receptor [2].
This was confirmed by measurements of purified plasma membrane Na,K-ATPase activity after incubation with recombinant TCTP and SNX6 [3].

Other interactions of SNX6

1. We focused on three genes, SNX6, NPAS3, and C14ORF11, as potential candidates for HPE [4].
Inhibition of Na,K-ATPase-suppressive activity of translationally controlled tumor protein by sorting nexin 6 [3].

References

Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases. Parks, W.T., Frank, D.B., Huff, C., Renfrew Haft, C., Martin, J., Meng, X., de Caestecker, M.P., McNally, J.G., Reddi, A., Taylor, S.I., Roberts, A.B., Wang, T., Lechleider, R.J. J. Biol. Chem. (2001) [Pubmed]
A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer. Wassmer, T., Attar, N., Bujny, M.V., Oakley, J., Traer, C.J., Cullen, P.J. J. Cell. Sci. (2007) [Pubmed]
Inhibition of Na,K-ATPase-suppressive activity of translationally controlled tumor protein by sorting nexin 6. Yoon, T., Kim, M., Lee, K. FEBS Lett. (2006) [Pubmed]
Defining a holoprosencephaly locus on human chromosome 14q13 and characterization of potential candidate genes. Kamnasaran, D., Chen, C.P., Devriendt, K., Mehta, L., Cox, D.W. Genomics (2005) [Pubmed]

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