The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

SNX5  -  sorting nexin 5

Homo sapiens

Synonyms: Sorting nexin-5
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of SNX5

 

High impact information on SNX5

  • Clathrin isoform CHC22, a component of neuromuscular and myotendinous junctions, binds sorting nexin 5 and has increased expression during myogenesis and muscle regeneration [2].
  • A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer [3].
  • SNX5 forms heterodimers with SNX1 and this interaction is required for endosome association of SNX5 [4].
  • Time-lapse videomicroscopy revealed the highly dynamic extension of SNX5-labelled tubules and their departure from the macropinosome body to follow predefined paths towards the perinuclear region of the cell, before fusing with early endosomal acceptor membranes [4].
  • Therefore, SNX5 is localized to a subdomain of the early endosome distinct from EEA1 and, following EGF stimulation and elevation of PtdIns3,4P2, is also transiently recruited to the plasma membrane [5].
 

Biological context of SNX5

  • Using this screen, we identified two proteins, SNX5 and SNX6, that, when suppressed, induced a phenotype similar to that observed upon suppression of known retromer components [3].
 

Anatomical context of SNX5

  • Northern blot analysis of SNX5 showed the presence of alternatively spliced transcripts and different expression patterns in various human cancer cell lines and normal tissues [1].
  • In response to EGF stimulation, either the SNX5-PX domain or full-length SNX5 was rapidly recruited to the plasma membrane [5].
 

Associations of SNX5 with chemical compounds

  • These results indicate that SNX5 may have functions not only associated with endosomal sorting but also with the phosphoinositide-signalling pathway [5].
  • Using liposome-based binding assays, we have shown that the PX domain of SNX5 interacts not only with PtdIns3P but also with PtdIns3,4P2 [5].
 

Regulatory relationships of SNX5

  • Functionally, overexpression of SNX5 inhibits the degradation of EGFR [6].
 

Other interactions of SNX5

  • The intracellular localization of deletion mutants and fusions with green fluorescent protein showed that the C-terminal regions of SNX1 and SNX5 are responsible for their endosomal localization [7].
  • We found that overexpression of SNX5 increased FANCA protein levels [1].
  • Inhibitory regulation of EGF receptor degradation by sorting nexin 5 [6].
 

Analytical, diagnostic and therapeutic context of SNX5

References

  1. SNX5, a new member of the sorting nexin family, binds to the Fanconi anemia complementation group A protein. Otsuki, T., Kajigaya, S., Ozawa, K., Liu, J.M. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  2. Clathrin isoform CHC22, a component of neuromuscular and myotendinous junctions, binds sorting nexin 5 and has increased expression during myogenesis and muscle regeneration. Towler, M.C., Gleeson, P.A., Hoshino, S., Rahkila, P., Manalo, V., Ohkoshi, N., Ordahl, C., Parton, R.G., Brodsky, F.M. Mol. Biol. Cell (2004) [Pubmed]
  3. A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer. Wassmer, T., Attar, N., Bujny, M.V., Oakley, J., Traer, C.J., Cullen, P.J. J. Cell. Sci. (2007) [Pubmed]
  4. Visualisation of macropinosome maturation by the recruitment of sorting nexins. Kerr, M.C., Lindsay, M.R., Luetterforst, R., Hamilton, N., Simpson, F., Parton, R.G., Gleeson, P.A., Teasdale, R.D. J. Cell. Sci. (2006) [Pubmed]
  5. Sorting nexin 5 is localized to a subdomain of the early endosomes and is recruited to the plasma membrane following EGF stimulation. Merino-Trigo, A., Kerr, M.C., Houghton, F., Lindberg, A., Mitchell, C., Teasdale, R.D., Gleeson, P.A. J. Cell. Sci. (2004) [Pubmed]
  6. Inhibitory regulation of EGF receptor degradation by sorting nexin 5. Liu, H., Liu, Z.Q., Chen, C.X., Magill, S., Jiang, Y., Liu, Y.J. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  7. A large family of endosome-localized proteins related to sorting nexin 1. Teasdale, R.D., Loci, D., Houghton, F., Karlsson, L., Gleeson, P.A. Biochem. J. (2001) [Pubmed]
 
WikiGenes - Universities