Gene Review:
SNX1 - sorting nexin 1
Homo sapiens
Synonyms:
HsT17379, MGC8664, SNX1A, Sorting nexin-1, VPS5, ...
- Sorting nexin 1 down-regulation promotes colon tumorigenesis. Nguyen, L.N., Holdren, M.S., Nguyen, A.P., Furuya, M.H., Bianchini, M., Levy, E., Mordoh, J., Liu, A., Guncay, G.D., Campbell, J.S., Parks, W.T. Clin. Cancer Res. (2006)
- SNX5, a new member of the sorting nexin family, binds to the Fanconi anemia complementation group A protein. Otsuki, T., Kajigaya, S., Ozawa, K., Liu, J.M. Biochem. Biophys. Res. Commun. (1999)
- RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking. Zheng, B., Ma, Y.C., Ostrom, R.S., Lavoie, C., Gill, G.N., Insel, P.A., Huang, X.Y., Farquhar, M.G. Science (2001)
- Enhanced degradation of EGF receptors by a sorting nexin, SNX1. Kurten, R.C., Cadena, D.L., Gill, G.N. Science (1996)
- Endosomal localization and function of sorting nexin 1. Zhong, Q., Lazar, C.S., Tronchère, H., Sato, T., Meerloo, T., Yeo, M., Songyang, Z., Emr, S.D., Gill, G.N. Proc. Natl. Acad. Sci. U.S.A. (2002)
- A role for sorting nexin 2 in epidermal growth factor receptor down-regulation: evidence for distinct functions of sorting nexin 1 and 2 in protein trafficking. Gullapalli, A., Garrett, T.A., Paing, M.M., Griffin, C.T., Yang, Y., Trejo, J. Mol. Biol. Cell (2004)
- Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor. Chin, L.S., Raynor, M.C., Wei, X., Chen, H.Q., Li, L. J. Biol. Chem. (2001)
- A large family of endosome-localized proteins related to sorting nexin 1. Teasdale, R.D., Loci, D., Houghton, F., Karlsson, L., Gleeson, P.A. Biochem. J. (2001)
- Identification of a family of sorting nexin molecules and characterization of their association with receptors. Haft, C.R., de la Luz Sierra, M., Barr, V.A., Haft, D.H., Taylor, S.I. Mol. Cell. Biol. (1998)
- Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors. Rojas, R., Kametaka, S., Haft, C.R., Bonifacino, J.S. Mol. Cell. Biol. (2007)
- The phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation. Cozier, G.E., Carlton, J., McGregor, A.H., Gleeson, P.A., Teasdale, R.D., Mellor, H., Cullen, P.J. J. Biol. Chem. (2002)
- Self-assembly and binding of a sorting nexin to sorting endosomes. Kurten, R.C., Eddington, A.D., Chowdhury, P., Smith, R.D., Davidson, A.D., Shank, B.B. J. Cell. Sci. (2001)
- Down-regulation of protease-activated receptor-1 is regulated by sorting nexin 1. Wang, Y., Zhou, Y., Szabo, K., Haft, C.R., Trejo, J. Mol. Biol. Cell (2002)
- Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides. Carlton, J., Bujny, M., Peter, B.J., Oorschot, V.M., Rutherford, A., Mellor, H., Klumperman, J., McMahon, H.T., Cullen, P.J. Curr. Biol. (2004)
- Enterophilin-1, a new partner of sorting nexin 1, decreases cell surface epidermal growth factor receptor. Pons, V., Hullin-Matsuda, F., Nauze, M., Barbaras, R., Pérès, C., Collet, X., Perret, B., Chap, H., Gassama-Diagne, A. J. Biol. Chem. (2003)
- An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins. Gullapalli, A., Wolfe, B.L., Griffin, C.T., Magnuson, T., Trejo, J. Mol. Biol. Cell (2006)
- A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP). Heydorn, A., Søndergaard, B.P., Ersbøll, B., Holst, B., Nielsen, F.C., Haft, C.R., Whistler, J., Schwartz, T.W. J. Biol. Chem. (2004)
- Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases. Parks, W.T., Frank, D.B., Huff, C., Renfrew Haft, C., Martin, J., Meng, X., de Caestecker, M.P., McNally, J.G., Reddi, A., Taylor, S.I., Roberts, A.B., Wang, T., Lechleider, R.J. J. Biol. Chem. (2001)
- A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer. Wassmer, T., Attar, N., Bujny, M.V., Oakley, J., Traer, C.J., Cullen, P.J. J. Cell. Sci. (2007)
- Overexpression of a novel sorting nexin, SNX15, affects endosome morphology and protein trafficking. Barr, V.A., Phillips, S.A., Taylor, S.I., Haft, C.R. Traffic (2000)
- Structural and functional characterization of the human gene for sorting nexin 1 (SNX1). Shank, B.B., Wiley, H.S., Kurten, R.C. DNA Cell Biol. (2001)