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Gene Review:

Klf6 - Kruppel-like factor 6

Rattus norvegicus

Synonyms: Aa1017, CPBP, Copeb, Core promoter element-binding protein, Krueppel-like factor 6, ...

Kim, Y. et al., Kiang, J.G. et al.

Kiang, Lu, Tabaku, Bentley, Atkins, Tsokos,

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Disease relevance of Klf6

Similarly, hemorrhage increased the expression of inducible nitric oxide synthase and Kruppel-like factor 6 and decreased expression of Kruppel-like factor 4 [1].

High impact information on Klf6

Zf9 transactivated the full-length TGF-beta1 promoter in either primary HSCs, HSC-T6 cells (an SV40-immortalized rat HSC line), Hep G2 cells, or Drosophila Schneider (S2) cells [2].

Biological context of Klf6

Nuclear extracts from culture-activated HSCs bound avidly by electrophoretic mobility shift assay to two tandem GC boxes within the TGF-beta1 promoter but minimally to a single GC box; these results correlated with transactivation by Zf9 of TGF-beta1 promoter-reporters [2].

References

Resuscitation with lactated Ringer solution limits the expression of molecular events associated with lung injury after hemorrhage. Kiang, J.G., Lu, X., Tabaku, L.S., Bentley, T.B., Atkins, J.L., Tsokos, G.C. J. Appl. Physiol. (2005) [Pubmed]
Transcriptional activation of transforming growth factor beta1 and its receptors by the Kruppel-like factor Zf9/core promoter-binding protein and Sp1. Potential mechanisms for autocrine fibrogenesis in response to injury. Kim, Y., Ratziu, V., Choi, S.G., Lalazar, A., Theiss, G., Dang, Q., Kim, S.J., Friedman, S.L. J. Biol. Chem. (1998) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

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klf6a	Danio rerio
KLF6	Gallus gallus
KLF6	Homo sapiens
LOC710784	Macaca mulatta
Klf6	Mus musculus
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klf6	Xenopus (Silurana) tropicalis

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