Gene Review:
Tgfb1 - transforming growth factor, beta 1
Rattus norvegicus
Synonyms:
TGF-beta-1, Transforming growth factor beta-1
- Soluble transforming growth factor-beta type II receptor inhibits negative remodeling, fibroblast transdifferentiation, and intimal lesion formation but not endothelial growth. Smith, J.D., Bryant, S.R., Couper, L.L., Vary, C.P., Gotwals, P.J., Koteliansky, V.E., Lindner, V. Circ. Res. (1999)
- Activation of the transforming growth factor beta signaling pathway and induction of cytostasis and apoptosis in mammary carcinomas treated with the anticancer agent perillyl alcohol. Ariazi, E.A., Satomi, Y., Ellis, M.J., Haag, J.D., Shi, W., Sattler, C.A., Gould, M.N. Cancer Res. (1999)
- Antisense oligonucleotides against thrombospondin-1 inhibit activation of tgf-beta in fibrotic renal disease in the rat in vivo. Daniel, C., Takabatake, Y., Mizui, M., Isaka, Y., Kawashi, H., Rupprecht, H., Imai, E., Hugo, C. Am. J. Pathol. (2003)
- Inhibition of bacterial cell wall-induced leukocyte recruitment and hepatic granuloma formation by TGF-beta gene transfer. Song, X., Zeng, L., Pilo, C.M., Zagorski, J., Wahl, S.M. J. Immunol. (1999)
- Transfer of the active form of transforming growth factor-beta 1 gene to newborn rat lung induces changes consistent with bronchopulmonary dysplasia. Gauldie, J., Galt, T., Bonniaud, P., Robbins, C., Kelly, M., Warburton, D. Am. J. Pathol. (2003)
- Clusterin expression by astrocytes is influenced by transforming growth factor beta 1 and heterotypic cell interactions. Morgan, T.E., Laping, N.J., Rozovsky, I., Oda, T., Hogan, T.H., Finch, C.E., Pasinetti, G.M. J. Neuroimmunol. (1995)
- Transforming growth factor-beta activated during exercise in brain depresses spontaneous motor activity of animals. Relevance To central fatigue. Inoue, K., Yamazaki, H., Manabe, Y., Fukuda, C., Hanai, K., Fushiki, T. Brain Res. (1999)
- Expression of transforming growth factor-beta1 in penile tissue from rats with bilateral cavernosal nerve ablation. Hu, W.L., Hu, L.Q., Li, S.W., Zheng, X.M., Tian, B.C. BJU international. (2004)
- Rat mandibular distraction osteogenesis: II. Molecular analysis of transforming growth factor beta-1 and osteocalcin gene expression. Mehrara, B.J., Rowe, N.M., Steinbrech, D.S., Dudziak, M.E., Saadeh, P.B., McCarthy, J.G., Gittes, G.K., Longaker, M.T. Plast. Reconstr. Surg. (1999)
- A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability. Woitach, J.T., Zhang, M., Niu, C.H., Thorgeirsson, S.S. Nat. Genet. (1998)
- Expression cloning and characterization of the TGF-beta type III receptor. Wang, X.F., Lin, H.Y., Ng-Eaton, E., Downward, J., Lodish, H.F., Weinberg, R.A. Cell (1991)
- A nuclear factor 1 binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-beta. Rossi, P., Karsenty, G., Roberts, A.B., Roche, N.S., Sporn, M.B., de Crombrugghe, B. Cell (1988)
- Combining TGF-beta inhibition and angiotensin II blockade results in enhanced antifibrotic effect. Yu, L., Border, W.A., Anderson, I., McCourt, M., Huang, Y., Noble, N.A. Kidney Int. (2004)
- Gene therapy by transforming growth factor-beta receptor-IgG Fc chimera suppressed extracellular matrix accumulation in experimental glomerulonephritis. Isaka, Y., Akagi, Y., Ando, Y., Tsujie, M., Sudo, T., Ohno, N., Border, W.A., Noble, N.A., Kaneda, Y., Hori, M., Imai, E. Kidney Int. (1999)
- Basic fibroblast growth factor induces TGF-beta release in an isoform and glioma-specific manner. Dhandapani, K.M., Wade, M.F., Mahesh, V.B., Brann, D.W. Neuroreport (2002)
- Norepinephrine enhances fibrosis mediated by TGF-beta in cardiac fibroblasts. Akiyama-Uchida, Y., Ashizawa, N., Ohtsuru, A., Seto, S., Tsukazaki, T., Kikuchi, H., Yamashita, S., Yano, K. Hypertension (2002)
- JinSanE Decoction, A Chinese Herbal Medicine, Inhibits Expression of TGF-beta1/Smads in Experimental Hepatic Fibrosis in Rats. Song, S.L., Gong, Z.J., Huang, Y.Q., Zhang, Q.R., Huang, T.X. Am. J. Chin. Med. (2006)
- Increased smad expression and activation are associated with apoptosis in normal and malignant prostate after castration. Brodin, G., ten Dijke, P., Funa, K., Heldin, C.H., Landström, M. Cancer Res. (1999)
- Epidermal growth factor impairs the cytochrome C/caspase-3 apoptotic pathway induced by transforming growth factor beta in rat fetal hepatocytes via a phosphoinositide 3-kinase-dependent pathway. Fabregat, I., Herrera, B., Fernández, M., Alvarez, A.M., Sánchez, A., Roncero, C., Ventura, J.J., Valverde, A.M., Benito, M. Hepatology (2000)
- Regulation of transforming growth factor beta receptors in H-ras oncogene-transformed rat intestinal epithelial cells. Zhao, J., Buick, R.N. Cancer Res. (1995)
- Radiation-induced alterations in rat mesangial cell Tgfb1 and Tgfb3 gene expression are not associated with altered secretion of active Tgfb isoforms. O'Malley, Y., Zhao, W., Barcellos-Hoff, M.H., Robbins, M.E. Radiat. Res. (1999)
- Involvement of wound-associated factors in rat brain astrocyte migratory response to axonal injury: in vitro simulation. Faber-Elman, A., Solomon, A., Abraham, J.A., Marikovsky, M., Schwartz, M. J. Clin. Invest. (1996)
- TGF-beta promotes proliferation of cultured SMC via both PDGF-AA-dependent and PDGF-AA-independent mechanisms. Stouffer, G.A., Owens, G.K. J. Clin. Invest. (1994)
- Cytokine modulation of intestinal epithelial cell restitution: central role of transforming growth factor beta. Dignass, A.U., Podolsky, D.K. Gastroenterology (1993)
- Glucose up-regulates thrombospondin 1 gene transcription and transforming growth factor-beta activity through antagonism of cGMP-dependent protein kinase repression via upstream stimulatory factor 2. Wang, S., Skorczewski, J., Feng, X., Mei, L., Murphy-Ullrich, J.E. J. Biol. Chem. (2004)
- Induction of transforming growth factor-beta during cardiac allograft rejection. Waltenberger, J., Wanders, A., Fellström, B., Miyazono, K., Heldin, C.H., Funa, K. J. Immunol. (1993)
- Ursodeoxycholic acid modulates E2F-1 and p53 expression through a caspase-independent mechanism in transforming growth factor beta1-induced apoptosis of rat hepatocytes. Sola, S., Ma, X., Castro, R.E., Kren, B.T., Steer, C.J., Rodrigues, C.M. J. Biol. Chem. (2003)
- The functional interaction between the paired domain transcription factor Pax8 and Smad3 is involved in transforming growth factor-beta repression of the sodium/iodide symporter gene. Costamagna, E., García, B., Santisteban, P. J. Biol. Chem. (2004)
- The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid-imidazolide alters transforming growth factor beta-dependent signaling and cell migration by affecting the cytoskeleton and the polarity complex. To, C., Kulkarni, S., Pawson, T., Honda, T., Gribble, G.W., Sporn, M.B., Wrana, J.L., Di Guglielmo, G.M. J. Biol. Chem. (2008)
- Transforming growth factor beta (TGF-beta) signaling is regulated by electrical activity in skeletal muscle cells. TGF-beta type I receptor is transcriptionally regulated by myotube excitability. Ugarte, G., Brandan, E. J. Biol. Chem. (2006)
- Transcription factor Ets-1 is essential for mesangial matrix remodeling. Mizui, M., Isaka, Y., Takabatake, Y., Sato, Y., Kawachi, H., Shimizu, F., Takahara, S., Ito, T., Imai, E. Kidney Int. (2006)
- Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity. Tolsma, S.S., Volpert, O.V., Good, D.J., Frazier, W.A., Polverini, P.J., Bouck, N. J. Cell Biol. (1993)
- TGF-beta 1 in glomerulosclerosis and interstitial fibrosis of adriamycin nephropathy. Tamaki, K., Okuda, S., Ando, T., Iwamoto, T., Nakayama, M., Fujishima, M. Kidney Int. (1994)
- Angiotensin II-induced transactivation of epidermal growth factor receptor regulates fibronectin and transforming growth factor-beta synthesis via transcriptional and posttranscriptional mechanisms. Moriguchi, Y., Matsubara, H., Mori, Y., Murasawa, S., Masaki, H., Maruyama, K., Tsutsumi, Y., Shibasaki, Y., Tanaka, Y., Nakajima, T., Oda, K., Iwasaka, T. Circ. Res. (1999)
- Transforming growth factor-beta 1 responsiveness of the rat osteocalcin gene is mediated by an activator protein-1 binding site. Banerjee, C., Stein, J.L., Van Wijnen, A.J., Frenkel, B., Lian, J.B., Stein, G.S. Endocrinology (1996)
- Expression of hepatocyte growth factor mRNA in rat liver cirrhosis induced by N-nitrosodimethylamine as evidenced by in situ RT-PCR. Hata, J., Ikeda, E., Uno, H., Asano, S. J. Histochem. Cytochem. (2002)
- Site-specific responses to monocrotaline-induced vascular injury: evidence for two distinct mechanisms of remodeling. Tanaka, Y., Bernstein, M.L., Mecham, R.P., Patterson, G.A., Cooper, J.D., Botney, M.D. Am. J. Respir. Cell Mol. Biol. (1996)
- Identification of an inhibitor targeting macrophage production of monocyte chemoattractant protein-1 as TGF-beta 1. Kitamura, M. J. Immunol. (1997)
- Smad7 inhibits fibrotic effect of TGF-Beta on renal tubular epithelial cells by blocking Smad2 activation. Li, J.H., Zhu, H.J., Huang, X.R., Lai, K.N., Johnson, R.J., Lan, H.Y. J. Am. Soc. Nephrol. (2002)
- Evidence for low-density lipoprotein-induced expression of connective tissue growth factor in mesangial cells. Sohn, M., Tan, Y., Klein, R.L., Jaffa, A.A. Kidney Int. (2005)
- Antiproliferative action of calcitonin on lactotrophs of the rat anterior pituitary gland: evidence for the involvement of transforming growth factor beta 1 in calcitonin action. Wang, Y.Q., Yuan, R., Sun, Y.P., Lee, T.J., Shah, G.V. Endocrinology (2003)
- Transforming growth factor-beta promotes recruitment of bone marrow cells and bone marrow-derived mesenchymal stem cells through stimulation of MCP-1 production in vascular smooth muscle cells. Zhang, F., Tsai, S., Kato, K., Yamanouchi, D., Wang, C., Rafii, S., Liu, B., Kent, K.C. J. Biol. Chem. (2009)
- Inhibition of rat hepatocyte proliferation by transforming growth factor beta and glucagon is associated with inhibition of ERK2 and p70 S6 kinase. Dixon, M., Agius, L., Yeaman, S.J., Day, C.P. Hepatology (1999)
- Id1 is a critical mediator in TGF-beta-induced transdifferentiation of rat hepatic stellate cells. Wiercinska, E., Wickert, L., Denecke, B., Said, H.M., Hamzavi, J., Gressner, A.M., Thorikay, M., ten Dijke, P., Mertens, P.R., Breitkopf, K., Dooley, S. Hepatology (2006)
- Cytokine mRNA expression in postischemic/reperfused myocardium. Herskowitz, A., Choi, S., Ansari, A.A., Wesselingh, S. Am. J. Pathol. (1995)
- Insulin-like growth factor-I inhibits transcriptional responses of transforming growth factor-beta by phosphatidylinositol 3-kinase/Akt-dependent suppression of the activation of Smad3 but not Smad2. Song, K., Cornelius, S.C., Reiss, M., Danielpour, D. J. Biol. Chem. (2003)
- Transforming growth factor-beta 1 is the predominant paracrine inhibitor of macrophage cytokine synthesis produced by glomerular mesangial cells . Kitamura, M., Sütö, T., Yokoo, T., Shimizu, F., Fine, L.G. J. Immunol. (1996)