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Gene Review

KLF6  -  Kruppel-like factor 6

Homo sapiens

Synonyms: B-cell-derived protein 1, BCD1, CBA1, COPEB, CPBP, ...
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Disease relevance of KLF6


High impact information on KLF6


Chemical compound and disease context of KLF6


Biological context of KLF6


Anatomical context of KLF6


Associations of KLF6 with chemical compounds

  • Loss of growth suppressive function of the CRC-derived KLF6 mutants was characterized by in vitro thymidine incorporation assays and Western blotting [2].
  • Direct lysine acetylation of KLF6 peptides can be shown by mass spectrometry [9].
  • Our data suggest a minor role of KLF6 mutation in colorectal carcinogenesis and underline the fact that the validity of sequence informations obtained from DNA extracted from formalin-fixed tissues may be limited [15].
  • We also show that all KLF6 effects on c-Jun were largely dependent on phorbol ester (TPA/ionomycin) extracellular stimulation, which enhanced KLF6 nuclear translocation and transcriptional activity and modified its phosphorylation status [16].
  • Treatment of two cell lines expressing KLF6 at low levels with 5-azacytidine did not induce KLF6 expression, suggesting that KLF6 down-regulation is not due to promoter hypermethylation [17].

Physical interactions of KLF6


Regulatory relationships of KLF6


Other interactions of KLF6

  • Rates of KLF6 loss and mutation were similar to those of TP53 and K-RAS in the same samples [2].
  • MXI1, DMBT1, and KLF6 were excluded as important tumor-suppressor genes [23].
  • Furthermore, we demonstrate that there is a physical interaction between GKLF and Zf9, a novel finding for Krüppel-like family members [13].
  • The Krüppel-like transcriptional factors Zf9 and GKLF coactivate the human keratin 4 promoter and physically interact [13].
  • Here we report the identification of Luna, the Drosophila progenitor of the mammalian KLF6/KLF7 group [24].
  • Results obtained showed that IGF-I stimulated KLF-6 transcription in cells with normal, but not disrupted, p53, suggesting that KLF6 is a downstream target for IGF-I action [25].

Analytical, diagnostic and therapeutic context of KLF6


  1. KLF6, a candidate tumor suppressor gene mutated in prostate cancer. Narla, G., Heath, K.E., Reeves, H.L., Li, D., Giono, L.E., Kimmelman, A.C., Glucksman, M.J., Narla, J., Eng, F.J., Chan, A.M., Ferrari, A.C., Martignetti, J.A., Friedman, S.L. Science (2001) [Pubmed]
  2. Kruppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer. Reeves, H.L., Narla, G., Ogunbiyi, O., Haq, A.I., Katz, A., Benzeno, S., Hod, E., Harpaz, N., Goldberg, S., Tal-Kremer, S., Eng, F.J., Arthur, M.J., Martignetti, J.A., Friedman, S.L. Gastroenterology (2004) [Pubmed]
  3. Cyclin-dependent kinase inhibition by the KLF6 tumor suppressor protein through interaction with cyclin D1. Benzeno, S., Narla, G., Allina, J., Cheng, G.Z., Reeves, H.L., Banck, M.S., Odin, J.A., Diehl, J.A., Germain, D., Friedman, S.L. Cancer Res. (2004) [Pubmed]
  4. Transcriptional activation of the human inducible nitric-oxide synthase promoter by Kruppel-like factor 6. Warke, V.G., Nambiar, M.P., Krishnan, S., Tenbrock, K., Geller, D.A., Koritschoner, N.P., Atkins, J.L., Farber, D.L., Tsokos, G.C. J. Biol. Chem. (2003) [Pubmed]
  5. OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins. Strubin, M., Newell, J.W., Matthias, P. Cell (1995) [Pubmed]
  6. Further evidence that "malignant angioendotheliomatosis" is an angiotropic large-cell lymphoma. Sheibani, K., Battifora, H., Winberg, C.D., Burke, J.S., Ben-Ezra, J., Ellinger, G.M., Quigley, N.J., Fernandez, B.B., Morrow, D., Rappaport, H. N. Engl. J. Med. (1986) [Pubmed]
  7. Specific chromosomal translocations and the genesis of B-cell-derived tumors in mice and men. Klein, G. Cell (1983) [Pubmed]
  8. Rat c-myc oncogene is located on chromosome 7 and rearranges in immunocytomas with t(6:7) chromosomal translocation. Sümegi, J., Spira, J., Bazin, H., Szpirer, J., Levan, G., Klein, G. Nature (1983) [Pubmed]
  9. Regulation of Kruppel-like factor 6 tumor suppressor activity by acetylation. Li, D., Yea, S., Dolios, G., Martignetti, J.A., Narla, G., Wang, R., Walsh, M.J., Friedman, S.L. Cancer Res. (2005) [Pubmed]
  10. Aberrant expression of krUppel-like factor 6 protein in colorectal cancers. Cho, Y.G., Choi, B.J., Song, J.W., Kim, S.Y., Nam, S.W., Lee, S.H., Yoo, N.J., Lee, J.Y., Park, W.S. World J. Gastroenterol. (2006) [Pubmed]
  11. Krüppel-like factor-6 promotes preadipocyte differentiation through histone deacetylase 3-dependent repression of DLK1. Li, D., Yea, S., Li, S., Chen, Z., Narla, G., Banck, M., Laborda, J., Tan, S., Friedman, J.M., Friedman, S.L., Walsh, M.J. J. Biol. Chem. (2005) [Pubmed]
  12. Transcriptional activation of the insulin-like growth factor I receptor gene by the Kruppel-like factor 6 (KLF6) tumor suppressor protein: potential interactions between KLF6 and p53. Rubinstein, M., Idelman, G., Plymate, S.R., Narla, G., Friedman, S.L., Werner, H. Endocrinology (2004) [Pubmed]
  13. The Krüppel-like transcriptional factors Zf9 and GKLF coactivate the human keratin 4 promoter and physically interact. Okano, J., Opitz, O.G., Nakagawa, H., Jenkins, T.D., Friedman, S.L., Rustgi, A.K. FEBS Lett. (2000) [Pubmed]
  14. Suppression of glioblastoma tumorigenicity by the Kruppel-like transcription factor KLF6. Kimmelman, A.C., Qiao, R.F., Narla, G., Banno, A., Lau, N., Bos, P.D., Nuñez Rodriguez, N., Liang, B.C., Guha, A., Martignetti, J.A., Friedman, S.L., Chan, A.M. Oncogene (2004) [Pubmed]
  15. Absence of mutation in the putative tumor-suppressor gene KLF6 in colorectal cancers. Lièvre, A., Landi, B., Côté, J.F., Veyrie, N., Zucman-Rossi, J., Berger, A., Laurent-Puig, P. Oncogene (2005) [Pubmed]
  16. A new role for the Kruppel-like transcription factor KLF6 as an inhibitor of c-Jun proto-oncoprotein function. Slavin, D.A., Koritschoner, N.P., Prieto, C.C., López-Díaz, F.J., Chatton, B., Bocco, J.L. Oncogene (2004) [Pubmed]
  17. Krüppel-like factor 6 is frequently down-regulated and induces apoptosis in non-small cell lung cancer cells. Ito, G., Uchiyama, M., Kondo, M., Mori, S., Usami, N., Maeda, O., Kawabe, T., Hasegawa, Y., Shimokata, K., Sekido, Y. Cancer Res. (2004) [Pubmed]
  18. Activation of the human pregnancy-specific glycoprotein PSG-5 promoter by KLF4 and Sp1. Blanchon, L., Nores, R., Gallot, D., Marceau, G., Borel, V., Yang, V.W., Bocco, J.L., Lémery, D., Panzetta-Dutari, G., Sapin, V. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  19. Disruption of an SP2/KLF6 Repression Complex by SHP Is Required for Farnesoid X Receptor-induced Endothelial Cell Migration. Das, A., Fernandez-Zapico, M.E., Cao, S., Yao, J., Fiorucci, S., Hebbel, R.P., Urrutia, R., Shah, V.H. J. Biol. Chem. (2006) [Pubmed]
  20. Evaluation of platelet activation and cytokine release during storage of platelet concentrates processed from buffy coats either manually or by the automated OrbiSac system. Vetlesen, A., Mirlashari, M.R., Ezligini, F., Kjeldsen-Kragh, J. Transfusion (2007) [Pubmed]
  21. CD3xCD19 bispecific antibodies and CD28 bivalent antibodies enhance T-cell reactivity against autologous leukemic cells in pediatric B-ALL bone marrow. Manzke, O., Berthold, F., Huebel, K., Tesch, H., Diehl, V., Bohlen, H. Int. J. Cancer (1999) [Pubmed]
  22. Megakaryocyte-targeted synthesis of the integrin beta(3)-subunit results in the phenotypic correction of Glanzmann thrombasthenia. Wilcox, D.A., Olsen, J.C., Ishizawa, L., Bray, P.F., French, D.L., Steeber, D.A., Bell, W.R., Griffith, M., White, G.C. Blood (2000) [Pubmed]
  23. Loss of a small region around the PTEN locus is a major chromosome 10 alteration in prostate cancer xenografts and cell lines. Hermans, K.G., van Alewijk, D.C., Veltman, J.A., van Weerden, W., van Kessel, A.G., Trapman, J. Genes Chromosomes Cancer (2004) [Pubmed]
  24. Identification of the Drosophila progenitor of mammalian Krüppel-like factors 6 and 7 and a determinant of fly development. De Graeve, F., Smaldone, S., Laub, F., Mlodzik, M., Bhat, M., Ramirez, F. Gene (2003) [Pubmed]
  25. Insulin-like growth factor-i regulates Kruppel-like factor-6 gene expression in a p53-dependent manner. Bentov, I., Narla, G., Schayek, H., Akita, K., Plymate, S.R., LeRoith, D., Friedman, S.L., Werner, H. Endocrinology (2008) [Pubmed]
  26. Deletion, mutation, and loss of expression of KLF6 in human prostate cancer. Chen, C., Hyytinen, E.R., Sun, X., Helin, H.J., Koivisto, P.A., Frierson, H.F., Vessella, R.L., Dong, J.T. Am. J. Pathol. (2003) [Pubmed]
  27. Kruppel-like factor 6 (KLF6) affects the promoter activity of the alpha1-proteinase inhibitor gene. Chiambaretta, F., Nakamura, H., De Graeve, F., Sakai, H., Marceau, G., Maruyama, Y., Rigal, D., Dastugue, B., Sugar, J., Yue, B.Y., Sapin, V. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
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