Gene Review:
KLF6 - Kruppel-like factor 6
Homo sapiens
Synonyms:
B-cell-derived protein 1, BCD1, CBA1, COPEB, CPBP, ...
Kjeldsen-Kragh,
Hebbel,
Ezligini,
Das,
Urrutia,
Mirlashari,
Fiorucci,
Cao,
Fernandez-Zapico,
Vetlesen,
Yao,
Shah,
- KLF6, a candidate tumor suppressor gene mutated in prostate cancer. Narla, G., Heath, K.E., Reeves, H.L., Li, D., Giono, L.E., Kimmelman, A.C., Glucksman, M.J., Narla, J., Eng, F.J., Chan, A.M., Ferrari, A.C., Martignetti, J.A., Friedman, S.L. Science (2001)
- Kruppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer. Reeves, H.L., Narla, G., Ogunbiyi, O., Haq, A.I., Katz, A., Benzeno, S., Hod, E., Harpaz, N., Goldberg, S., Tal-Kremer, S., Eng, F.J., Arthur, M.J., Martignetti, J.A., Friedman, S.L. Gastroenterology (2004)
- Cyclin-dependent kinase inhibition by the KLF6 tumor suppressor protein through interaction with cyclin D1. Benzeno, S., Narla, G., Allina, J., Cheng, G.Z., Reeves, H.L., Banck, M.S., Odin, J.A., Diehl, J.A., Germain, D., Friedman, S.L. Cancer Res. (2004)
- Transcriptional activation of the human inducible nitric-oxide synthase promoter by Kruppel-like factor 6. Warke, V.G., Nambiar, M.P., Krishnan, S., Tenbrock, K., Geller, D.A., Koritschoner, N.P., Atkins, J.L., Farber, D.L., Tsokos, G.C. J. Biol. Chem. (2003)
- OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins. Strubin, M., Newell, J.W., Matthias, P. Cell (1995)
- Further evidence that "malignant angioendotheliomatosis" is an angiotropic large-cell lymphoma. Sheibani, K., Battifora, H., Winberg, C.D., Burke, J.S., Ben-Ezra, J., Ellinger, G.M., Quigley, N.J., Fernandez, B.B., Morrow, D., Rappaport, H. N. Engl. J. Med. (1986)
- Specific chromosomal translocations and the genesis of B-cell-derived tumors in mice and men. Klein, G. Cell (1983)
- Rat c-myc oncogene is located on chromosome 7 and rearranges in immunocytomas with t(6:7) chromosomal translocation. Sümegi, J., Spira, J., Bazin, H., Szpirer, J., Levan, G., Klein, G. Nature (1983)
- Regulation of Kruppel-like factor 6 tumor suppressor activity by acetylation. Li, D., Yea, S., Dolios, G., Martignetti, J.A., Narla, G., Wang, R., Walsh, M.J., Friedman, S.L. Cancer Res. (2005)
- Aberrant expression of krUppel-like factor 6 protein in colorectal cancers. Cho, Y.G., Choi, B.J., Song, J.W., Kim, S.Y., Nam, S.W., Lee, S.H., Yoo, N.J., Lee, J.Y., Park, W.S. World J. Gastroenterol. (2006)
- Krüppel-like factor-6 promotes preadipocyte differentiation through histone deacetylase 3-dependent repression of DLK1. Li, D., Yea, S., Li, S., Chen, Z., Narla, G., Banck, M., Laborda, J., Tan, S., Friedman, J.M., Friedman, S.L., Walsh, M.J. J. Biol. Chem. (2005)
- Transcriptional activation of the insulin-like growth factor I receptor gene by the Kruppel-like factor 6 (KLF6) tumor suppressor protein: potential interactions between KLF6 and p53. Rubinstein, M., Idelman, G., Plymate, S.R., Narla, G., Friedman, S.L., Werner, H. Endocrinology (2004)
- The Krüppel-like transcriptional factors Zf9 and GKLF coactivate the human keratin 4 promoter and physically interact. Okano, J., Opitz, O.G., Nakagawa, H., Jenkins, T.D., Friedman, S.L., Rustgi, A.K. FEBS Lett. (2000)
- Suppression of glioblastoma tumorigenicity by the Kruppel-like transcription factor KLF6. Kimmelman, A.C., Qiao, R.F., Narla, G., Banno, A., Lau, N., Bos, P.D., Nuñez Rodriguez, N., Liang, B.C., Guha, A., Martignetti, J.A., Friedman, S.L., Chan, A.M. Oncogene (2004)
- Absence of mutation in the putative tumor-suppressor gene KLF6 in colorectal cancers. Lièvre, A., Landi, B., Côté, J.F., Veyrie, N., Zucman-Rossi, J., Berger, A., Laurent-Puig, P. Oncogene (2005)
- A new role for the Kruppel-like transcription factor KLF6 as an inhibitor of c-Jun proto-oncoprotein function. Slavin, D.A., Koritschoner, N.P., Prieto, C.C., López-Díaz, F.J., Chatton, B., Bocco, J.L. Oncogene (2004)
- Krüppel-like factor 6 is frequently down-regulated and induces apoptosis in non-small cell lung cancer cells. Ito, G., Uchiyama, M., Kondo, M., Mori, S., Usami, N., Maeda, O., Kawabe, T., Hasegawa, Y., Shimokata, K., Sekido, Y. Cancer Res. (2004)
- Activation of the human pregnancy-specific glycoprotein PSG-5 promoter by KLF4 and Sp1. Blanchon, L., Nores, R., Gallot, D., Marceau, G., Borel, V., Yang, V.W., Bocco, J.L., Lémery, D., Panzetta-Dutari, G., Sapin, V. Biochem. Biophys. Res. Commun. (2006)
- Disruption of an SP2/KLF6 Repression Complex by SHP Is Required for Farnesoid X Receptor-induced Endothelial Cell Migration. Das, A., Fernandez-Zapico, M.E., Cao, S., Yao, J., Fiorucci, S., Hebbel, R.P., Urrutia, R., Shah, V.H. J. Biol. Chem. (2006)
- Evaluation of platelet activation and cytokine release during storage of platelet concentrates processed from buffy coats either manually or by the automated OrbiSac system. Vetlesen, A., Mirlashari, M.R., Ezligini, F., Kjeldsen-Kragh, J. Transfusion (2007)
- CD3xCD19 bispecific antibodies and CD28 bivalent antibodies enhance T-cell reactivity against autologous leukemic cells in pediatric B-ALL bone marrow. Manzke, O., Berthold, F., Huebel, K., Tesch, H., Diehl, V., Bohlen, H. Int. J. Cancer (1999)
- Megakaryocyte-targeted synthesis of the integrin beta(3)-subunit results in the phenotypic correction of Glanzmann thrombasthenia. Wilcox, D.A., Olsen, J.C., Ishizawa, L., Bray, P.F., French, D.L., Steeber, D.A., Bell, W.R., Griffith, M., White, G.C. Blood (2000)
- Loss of a small region around the PTEN locus is a major chromosome 10 alteration in prostate cancer xenografts and cell lines. Hermans, K.G., van Alewijk, D.C., Veltman, J.A., van Weerden, W., van Kessel, A.G., Trapman, J. Genes Chromosomes Cancer (2004)
- Identification of the Drosophila progenitor of mammalian Krüppel-like factors 6 and 7 and a determinant of fly development. De Graeve, F., Smaldone, S., Laub, F., Mlodzik, M., Bhat, M., Ramirez, F. Gene (2003)
- Insulin-like growth factor-i regulates Kruppel-like factor-6 gene expression in a p53-dependent manner. Bentov, I., Narla, G., Schayek, H., Akita, K., Plymate, S.R., LeRoith, D., Friedman, S.L., Werner, H. Endocrinology (2008)
- Deletion, mutation, and loss of expression of KLF6 in human prostate cancer. Chen, C., Hyytinen, E.R., Sun, X., Helin, H.J., Koivisto, P.A., Frierson, H.F., Vessella, R.L., Dong, J.T. Am. J. Pathol. (2003)
- Kruppel-like factor 6 (KLF6) affects the promoter activity of the alpha1-proteinase inhibitor gene. Chiambaretta, F., Nakamura, H., De Graeve, F., Sakai, H., Marceau, G., Maruyama, Y., Rigal, D., Dastugue, B., Sugar, J., Yue, B.Y., Sapin, V. Invest. Ophthalmol. Vis. Sci. (2006)