Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

RALB - v-ral simian leukemia viral oncogene...

Homo sapiens

Synonyms: Ras-related protein Ral-B

Morrow, J.A. et al., Umberkoman-Wiita, B. et al., Chien, Y. et al., Hsieh, C.L. et al.

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High impact information on RALB

Here, we show that RALA and RALB collaborate to maintain tumorigenicity through regulation of both proliferation and survival [1].
The respective Ralb of these 2 globulins were similar to the testosterone-estradiol binding globulin and cortisol binding globulin in human serum [2].
The RALB gene, a new member of the ra1 family, has been isolated, sequenced, and assigned to human chromosome 2 cen-q13 [3].

Associations of RALB with chemical compounds

In C, RALB and RALA, the change in base excess from rest to postexercise was greater than the concomitant increase in blood lactate concentration, suggesting the presence of a significant amount of acid in the blood in addition to lactic acid [4].

References

RAL GTPases are linchpin modulators of human tumour-cell proliferation and survival. Chien, Y., White, M.A. EMBO Rep. (2003) [Pubmed]
Association of tritium-labelled estradiol, progesterone and 17 alpha-hydroxyprogesterone with the proteins of the serum and cerebrospinal fluid in the rhesus monkey. Umberkoman-Wiita, B., Anand Kumar, T.C. Neuroendocrinology (1979) [Pubmed]
Chromosomal localization and cDNA sequence of human ralB, a GTP binding protein. Hsieh, C.L., Swaroop, A., Francke, U. Somat. Cell Mol. Genet. (1990) [Pubmed]
Respiratory alkalosis: no effect on blood lactate decline or exercise performance. Morrow, J.A., Fell, R.D., Gladden, L.B. European journal of applied physiology and occupational physiology. (1988) [Pubmed]

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