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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Jph2  -  junctophilin 2

Mus musculus

Synonyms: 1110002E14Rik, JP-2, Jp2, Junctophilin type 2, Junctophilin-2
 
 
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Disease relevance of Jph2

  • Coaggregation of F. nucleatum PK1594 with P. gingivalis PK 1924 and Actinobacillus actinomycetemcomitans JP2, but not with other bacteria, showed a similar pattern with sugars, monoclonal antibody, and the adhesin-deficient mutant [1].
 

High impact information on Jph2

  • Of the three JP subtypes, both type 1 (JP-1) and type 2 (JP-2) are abundantly expressed in skeletal muscle [2].
  • These observations, together with other findings, suggest that the triad might be constructed in a JP-1-dependent manner after the achievement of JP-2-mediated diad formation during skeletal muscle maturation [3].
  • Junctophilins (JP-1, JP-2, and JP-3) are transmembrane proteins expressed in the junctional membrane complexes in excitable cells [4].
  • The present results strongly suggest that JP-1 and JP-2 play important roles in the formation of triads and diads, respectively, during the development of skeletal muscle in mouse [4].
  • Both JP-1 and JP-2 are co-expressed in the triads of skeletal muscle, but only JP-2 is expressed in cardiac muscle [4].
 

Biological context of Jph2

  • In the presence of the complementing plasmid, PAO-JP2 produced the mRNA for the above cytokines [5].
 

Anatomical context of Jph2

References

  1. Attachment of Fusobacterium nucleatum PK1594 to mammalian cells and its coaggregation with periodontopathogenic bacteria are mediated by the same galactose-binding adhesin. Weiss, E.I., Shaniztki, B., Dotan, M., Ganeshkumar, N., Kolenbrander, P.E., Metzger, Z. Oral Microbiol. Immunol. (2000) [Pubmed]
  2. Deficiency of triad junction and contraction in mutant skeletal muscle lacking junctophilin type 1. Ito, K., Komazaki, S., Sasamoto, K., Yoshida, M., Nishi, M., Kitamura, K., Takeshima, H. J. Cell Biol. (2001) [Pubmed]
  3. Abnormal junctional membrane structures in cardiac myocytes expressing ectopic junctophilin type 1. Komazaki, S., Nishi, M., Takeshima, H. FEBS Lett. (2003) [Pubmed]
  4. Deficiency of triad formation in developing skeletal muscle cells lacking junctophilin type 1. Komazaki, S., Ito, K., Takeshima, H., Nakamura, H. FEBS Lett. (2002) [Pubmed]
  5. Cytokine induction by the P. aeruginosa quorum sensing system during thermal injury. Rumbaugh, K.P., Hamood, A.N., Griswold, J.A. J. Surg. Res. (2004) [Pubmed]
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