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MeSH Review


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Disease relevance of Actinobacillus

  • Pseudomonas sp. IFO-13309 and Actinobacillus sp. IFO-13310, bacteria which exhibit a symbiotic growth in a medium containing keratin sulfate as a sole carbon source, were isolated from soil [1].
  • We have previously shown that Actinobacillus actinomycetemcomitans produces an immunosuppressive factor that is encoded by the cdtB gene, which is homologous to a family of cytolethal distending toxins (Cdt) expressed by several gram-negative bacteria [2].
  • When the transfectants were exposed to freeze-dried periodontopathic bacteria, Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Capnocytophaga ochracea, and Fusobacterium nucleatum, and a non-oral bacterium, Escherichia coli, all species of the bacteria induced NF-kappaB-dependent CD25 expression in 7.7/huTLR2 cells [3].
  • The serotype b-specific carbohydrate antigen (SbAg) of Actinobacillus actinomycetemcomitans Y4 is reported to be the O antigen of lipopolysaccharide, and the highest titers of serum antibody reactive with A. actinomycetemcomitans in early-onset periodontitis (EOP) patients bind SbAg [4].
  • The susceptibilities of 87 periodontitis-associated strains of Actinobacillus actinomycetemcomitans to clarithromycin and erythromycin were determined by standard methodology recommended for Haemophilus influenzae [5].

High impact information on Actinobacillus


Chemical compound and disease context of Actinobacillus


Biological context of Actinobacillus


Anatomical context of Actinobacillus


Gene context of Actinobacillus


Analytical, diagnostic and therapeutic context of Actinobacillus


  1. Sequential degradation of keratan sulfate by bacterial enzymes and purification of a sulfatase in the enzymatic system. Nakazawa, K., Suzuki, N., Suzuki, S. J. Biol. Chem. (1975) [Pubmed]
  2. Expression of the cytolethal distending toxin (Cdt) operon in Actinobacillus actinomycetemcomitans: evidence that the CdtB protein is responsible for G2 arrest of the cell cycle in human T cells. Shenker, B.J., Hoffmaster, R.H., McKay, T.L., Demuth, D.R. J. Immunol. (2000) [Pubmed]
  3. Lipopolysaccharides from periodontopathic bacteria Porphyromonas gingivalis and Capnocytophaga ochracea are antagonists for human toll-like receptor 4. Yoshimura, A., Kaneko, T., Kato, Y., Golenbock, D.T., Hara, Y. Infect. Immun. (2002) [Pubmed]
  4. Heterogeneity of antibodies reactive with the dominant antigen of Actinobacillus actinomycetemcomitans. Nakashima, K., Schenkein, H.A., Califano, J.V., Tew, J.G. Infect. Immun. (1997) [Pubmed]
  5. Bacteriostatic and bactericidal in vitro activities of clarithromycin and erythromycin against periodontopathic Actinobacillus actinomycetemcomitans. Piccolomini, R., Catamo, G., Di Bonaventura, G. Antimicrob. Agents Chemother. (1998) [Pubmed]
  6. The potent bone-resorbing mediator of Actinobacillus actinomycetemcomitans is homologous to the molecular chaperone GroEL. Kirby, A.C., Meghji, S., Nair, S.P., White, P., Reddi, K., Nishihara, T., Nakashima, K., Willis, A.C., Sim, R., Wilson, M. J. Clin. Invest. (1995) [Pubmed]
  7. Truncation of the lipopolysaccharide outer core affects susceptibility to antimicrobial peptides and virulence of Actinobacillus pleuropneumoniae serotype 1. Ramjeet, M., Deslandes, V., St Michael, F., Cox, A.D., Kobisch, M., Gottschalk, M., Jacques, M. J. Biol. Chem. (2005) [Pubmed]
  8. Thymidine diphosphate-6-deoxy-L-lyxo-4-hexulose reductase synthesizing dTDP-6-deoxy-L-talose from Actinobacillus actinomycetemcomitans. Nakano, Y., Suzuki, N., Yoshida, Y., Nezu, T., Yamashita, Y., Koga, T. J. Biol. Chem. (2000) [Pubmed]
  9. A novel NDP-6-deoxyhexosyl-4-ulose reductase in the pathway for the synthesis of thymidine diphosphate-D-fucose. Yoshida, Y., Nakano, Y., Nezu, T., Yamashita, Y., Koga, T. J. Biol. Chem. (1999) [Pubmed]
  10. Actinobacillus actinomycetemcomitans immunosuppressive protein is a member of the family of cytolethal distending toxins capable of causing a G2 arrest in human T cells. Shenker, B.J., McKay, T., Datar, S., Miller, M., Chowhan, R., Demuth, D. J. Immunol. (1999) [Pubmed]
  11. 6-Deoxy-D-talan and 6-deoxy-L-talan. Novel serotype-specific polysaccharide antigens from Actinobacillus actinomycetemcomitans. Shibuya, N., Amano, K., Azuma, J., Nishihara, T., Kitamura, Y., Noguchi, T., Koga, T. J. Biol. Chem. (1991) [Pubmed]
  12. Distribution of tetracycline resistance genes in Actinobacillus pleuropneumoniae isolates from Spain. Blanco, M., Gutiérrez-Martin, C.B., Rodríguez-Ferri, E.F., Roberts, M.C., Navas, J. Antimicrob. Agents Chemother. (2006) [Pubmed]
  13. Synergistic effects between amoxicillin, metronidazole, and the hydroxymetabolite of metronidazole against Actinobacillus actinomycetemcomitans. Pavicić, M.J., van Winkelhoff, A.J., de Graaff, J. Antimicrob. Agents Chemother. (1991) [Pubmed]
  14. Pharmacokinetics of florfenicol in healthy pigs and in pigs experimentally infected with Actinobacillus pleuropneumoniae. Liu, J., Fung, K.F., Chen, Z., Zeng, Z., Zhang, J. Antimicrob. Agents Chemother. (2003) [Pubmed]
  15. Characterization of the lipopolysaccharide from Actinobacillus actinomycetemcomitans Y4 and N27. Kiley, P., Holt, S.C. Infect. Immun. (1980) [Pubmed]
  16. Characterization of a streptomycin-sulfonamide resistance plasmid from Actinobacillus pleuropneumoniae. Willson, P.J., Deneer, H.G., Potter, A., Albritton, W. Antimicrob. Agents Chemother. (1989) [Pubmed]
  17. Cloning and molecular characterization of Cu,Zn superoxide dismutase from Actinobacillus pleuropneumoniae. Langford, P.R., Loynds, B.M., Kroll, J.S. Infect. Immun. (1996) [Pubmed]
  18. Safety, stability, and efficacy of noncapsulated mutants of Actinobacillus pleuropneumoniae for use in live vaccines. Inzana, T.J., Todd, J., Veit, H.P. Infect. Immun. (1993) [Pubmed]
  19. Long-term effect of heat shock protein 60 from Actinobacillus actinomycetemcomitans on epithelial cell viability and mitogen-activated protein kinases. Zhang, L., Pelech, S., Uitto, V.J. Infect. Immun. (2004) [Pubmed]
  20. Effect of ciprofloxacin on killing of Actinobacillus actinomycetemcomitans by polymorphonuclear leukocytes. Cacchillo, D.A., Walters, J.D. Antimicrob. Agents Chemother. (2002) [Pubmed]
  21. Characterization of an antiproliferative surface-associated protein from Actinobacillus actinomycetemcomitans which can be neutralized by sera from a proportion of patients with localized juvenile periodontitis. White, P.A., Wilson, M., Nair, S.P., Kirby, A.C., Reddi, K., Henderson, B. Infect. Immun. (1995) [Pubmed]
  22. Mouse interleukin-1 receptor antagonist induced by Actinobacillus actinomycetemcomitans lipopolysaccharide blocks the effects of interleukin-1 on bone resorption and osteoclast-like cell formation. Nishihara, T., Ohsaki, Y., Ueda, N., Saito, N., Mundy, G.R. Infect. Immun. (1994) [Pubmed]
  23. Immunosuppressive factor from Actinobacillus actinomycetemcomitans down regulates cytokine production. Kurita-Ochiai, T., Ochiai, K. Infect. Immun. (1996) [Pubmed]
  24. One of two human lactoferrin variants exhibits increased antibacterial and transcriptional activation activities and is associated with localized juvenile periodontitis. Velliyagounder, K., Kaplan, J.B., Furgang, D., Legarda, D., Diamond, G., Parkin, R.E., Fine, D.H. Infect. Immun. (2003) [Pubmed]
  25. p53-independent expression of p21(CIP1/WAF1) in plasmacytic cells during G(2) cell cycle arrest induced by Actinobacillus actinomycetemcomitans cytolethal distending toxin. Sato, T., Koseki, T., Yamato, K., Saiki, K., Konishi, K., Yoshikawa, M., Ishikawa, I., Nishihara, T. Infect. Immun. (2002) [Pubmed]
  26. Expression of IL-1 beta and IL-8 by human gingival epithelial cells in response to Actinobacillus actinomycetemcomitans. Uchida, Y., Shiba, H., Komatsuzawa, H., Takemoto, T., Sakata, M., Fujita, T., Kawaguchi, H., Sugai, M., Kurihara, H. Cytokine (2001) [Pubmed]
  27. Gingival fibroblast cytokine profiles in Actinobacillus actinomycetemcomitans-associated periodontitis. Dongari-Bagtzoglou, A.I., Ebersole, J.L. J. Periodontol. (1996) [Pubmed]
  28. Cloning of the gene encoding the Actinobacillus actinomycetemcomitans serotype b OmpA-like outer membrane protein. Komatsuzawa, H., Kawai, T., Wilson, M.E., Taubman, M.A., Sugai, M., Suginaka, H. Infect. Immun. (1999) [Pubmed]
  29. Relative avidity of serum immunoglobulin G antibody for the fimbria antigen of Actinobacillus actinomycetemcomitans in patients with adult periodontitis. Saito, A., Hosaka, Y., Nakagawa, T., Yamada, S., Okuda, K. Infect. Immun. (1993) [Pubmed]
  30. Molecular cloning and expression of ptxA, the gene encoding the 120-kilodalton cytotoxin of Actinobacillus pleuropneumoniae serotype 2. MacDonald, J., Rycroft, A.N. Infect. Immun. (1992) [Pubmed]
  31. Effect of iron restriction on the outer membrane proteins of Actinobacillus (Haemophilus) pleuropneumoniae. Deneer, H.G., Potter, A.A. Infect. Immun. (1989) [Pubmed]
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