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Gene Review

LGR6  -  leucine-rich repeat containing G protein...

Homo sapiens

Synonyms: FLJ14471, GPCR, Leucine-rich repeat-containing G-protein coupled receptor 6, UNQ6427/PRO21331, VTS20631
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Psychiatry related information on LGR6

  • Many drugs of abuse signal through receptors that couple to G proteins (GPCRs), so the factors that control GPCR signaling are likely to be important to the understanding of drug abuse [1].

High impact information on LGR6

  • RATIONALE: In cell culture systems, agonists can promote the phosphorylation and internalization of receptors coupled to G proteins (GPCR), leading to their desensitization [2].
  • This analysis revealed that GPR49, an orphan G Protein-Coupled Receptor (GPCR) is overexpressed in 66% (10/15) colon tumors compared with normal colon tissues [3].


  1. Regulators of G protein signaling (RGS proteins): novel central nervous system drug targets. Neubig, R.R. J. Pept. Res. (2002) [Pubmed]
  2. Effector antagonism by the regulators of G protein signalling (RGS) proteins causes desensitization of mu-opioid receptors in the CNS. Garzón, J., Rodríguez-Muñoz, M., de la Torre-Madrid, E., Sánchez-Blázquez, P. Psychopharmacology (Berl.) (2005) [Pubmed]
  3. Identification of overexpression of orphan G protein-coupled receptor GPR49 in human colon and ovarian primary tumors. McClanahan, T., Koseoglu, S., Smith, K., Grein, J., Gustafson, E., Black, S., Kirschmeier, P., Samatar, A.A. Cancer Biol. Ther. (2006) [Pubmed]
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