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Gene Review

NIF3L1  -  NIF3 NGG1 interacting factor 3-like 1 (S....

Homo sapiens

Synonyms: ALS2CR1, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 1 protein, CALS-7, GTP cyclohydrolase I, MDS015, ...
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Disease relevance of NIF3L1


High impact information on NIF3L1

  • We identified five novel WBSCR14-interacting proteins, four 14-3-3 isotypes and NIF3L1, which form a single polypeptide complex in mammalian cells [2].
  • In the present study we identified novel binding partners of human NIF3L1 by screening a HeLa cDNA-library using the yeast two-hybrid system [3].
  • We could show that the NIF3L1 protein is interacting with itself and with the NIF3L1 binding protein 1 (NIF3L1 BP1), a novel protein of 23.67kDa bearing a putative leucine zipper domain [3].
  • The mouse gene was mapped to chromosome 1, region C. Human NIF3L1 consists of seven exons spanning 14.5 kb of genomic DNA and is located on chromosome 2q33 [4].
  • The N and C terminal halves of the NIF3-like domains are involved in dimerization, while the PII domain forms trimeric contacts with symmetry related monomers [1].


  1. Structure of a conserved hypothetical protein SA1388 from S. aureus reveals a capped hexameric toroid with two PII domain lids and a dinuclear metal center. Saikatendu, K.S., Zhang, X., Kinch, L., Leybourne, M., Grishin, N.V., Zhang, H. BMC Struct. Biol. (2006) [Pubmed]
  2. The subcellular localization of the ChoRE-binding protein, encoded by the Williams-Beuren syndrome critical region gene 14, is regulated by 14-3-3. Merla, G., Howald, C., Antonarakis, S.E., Reymond, A. Hum. Mol. Genet. (2004) [Pubmed]
  3. Identification and characterization of NIF3L1 BP1, a novel cytoplasmic interaction partner of the NIF3L1 protein. Tascou, S., Kang, T.W., Trappe, R., Engel, W., Burfeind, P. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  4. Isolation and characterization of a novel human gene, NIF3L1, and its mouse ortholog, Nif3l1, highly conserved from bacteria to mammals. Tascou, S., Uedelhoven, J., Dixkens, C., Nayernia, K., Engel, W., Burfeind, P. Cytogenet. Cell Genet. (2000) [Pubmed]
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