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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

RNU7-86P  -  RNA, U7 small nuclear 86 pseudogene

Homo sapiens

Synonyms: HSU7.7/32B, RNU7P2, U7
 
 
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Disease relevance of RNU7P2

 

High impact information on RNU7P2

  • Efficient 3'-end processing of cell cycle-regulated mammalian histone premessenger RNAs (pre-mRNAs) requires an upstream stem-loop and a histone downstream element (HDE) that base pairs with the U7 small ribonucleoprotein [2].
  • We used Xenopus oocytes to ask whether compensatory length insertions in the human U7 RNA could restore the fidelity and efficiency of processing of mouse histone insertion pre-mRNAs [2].
  • In this genomic stretch of DNA we have identified sequence homologous to the U7 RNA gene including its potential regulatory elements [3].
  • Exon skipping with U7 gene transfer [4].
 

Biological context of RNU7P2

  • Yet, the noncomplementary insertion mutant U7 was shown to be active on insertion substrates further mutated to allow base pairing [2].

References

  1. Detection of a gene cluster that is dispensable for human herpesvirus 6 replication and latency. Kondo, K., Nozaki, H., Shimada, K., Yamanishi, K. J. Virol. (2003) [Pubmed]
  2. Length suppression in histone messenger RNA 3'-end maturation: processing defects of insertion mutant premessenger RNAs can be compensated by insertions into the U7 small nuclear RNA. Scharl, E.C., Steitz, J.A. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  3. Identification of a U7snRNA homologue mapping to the human Xq27.1 region, between the DXS1232 and DXS119 loci. Mostardini, M., Appierto, V., Pergolizzi, R., Zucchi, I., Mumm, S., DeBellis, G., Milanesi, L., Rogozin, I.B., Biunno, I. Gene (1997) [Pubmed]
  4. Exon skipping with U7 gene transfer. Scheuerbrandt, G. Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology / edited by the Gaetano Conte Academy for the study of striated muscle diseases. (2006) [Pubmed]
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