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Gene Review

SNORD13P1  -  small nucleolar RNA, C/D box 13 pseudogene 1

Homo sapiens

Synonyms: RNU13P1, U13, U13.32A
 
 
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Disease relevance of RNU13P1

  • The backbone torsion angles, which partially influence the local conformation of U12 and U14 in U1 and U3-hairpins, respectively, are probably locked in the trans conformation as in the case of U13 in the U2-hairpin [1].
 

High impact information on RNU13P1

  • The U3, U8 and U13 snoRNA genes are transcribed independently, whereas U14-U24, as well as E3, are located within introns of protein-coding genes, most of whose functions are linked to translation [2].
  • Fractionation of HeLa cells revealed that U8 and U13, like U3, reside in the nucleolus [3].
  • U3, U8 and U13 comprise a new class of mammalian snRNPs localized in the cell nucleolus [3].
  • We propose that U3, U8 and U13 comprise a new subset of mammalian snRNPs whose roles in ribosome biogenesis are discussed [3].
  • The unassigned sheep syntenic groups U8 and U13 are provisionally assigned to sheep chromosomes 8 and 21, respectively [4].
 

Biological context of RNU13P1

  • Three pseudogenes for human U13 snRNA belong to class III [5].
  • These pseudogenes belong to class III because they contain dispersed mismatches when compared to the previously determined U13 RNA sequence, an adenine-rich region at the 3' end, and short imperfect repeats flanking the 5' end of the coding sequence and the 3' end of the adenine-rich region [5].
 

Analytical, diagnostic and therapeutic context of RNU13P1

  • Sequence analysis revealed that one of these RNAs, 136 nucleotides long, is the human U8 homolog; while the other, 105 nucleotides long, represents a novel species which we designate U13 [3].
  • METHODS: Anthropometry, maturity status, functional and sport-specific parameters were assessed in elite, sub-elite, and non-elite youth players in four age groups: U13 (n = 117), U14 (n = 136), U15 (n = 138) and U16 (n = 99) [6].

References

  1. Structural basis for poor uracil excision from hairpin DNA. An NMR study. Ghosh, M., Rumpal, N., Varshney, U., Chary, K.V. Eur. J. Biochem. (2002) [Pubmed]
  2. A mammalian gene with introns instead of exons generating stable RNA products. Tycowski, K.T., Shu, M.D., Steitz, J.A. Nature (1996) [Pubmed]
  3. U3, U8 and U13 comprise a new class of mammalian snRNPs localized in the cell nucleolus. Tyc, K., Steitz, J.A. EMBO J. (1989) [Pubmed]
  4. Regional assignment of conserved reference loci anchors unassigned linkage and syntenic groups to ovine chromosomes. Ansari, H.A., Pearce, P.D., Maher, D.W., Broad, T.E. Genomics (1994) [Pubmed]
  5. Three pseudogenes for human U13 snRNA belong to class III. Baserga, S.J., Yang, X.D., Steitz, J.A. Gene (1991) [Pubmed]
  6. A multidisciplinary selection model for youth soccer: the Ghent Youth Soccer Project. Vaeyens, R., Malina, R.M., Janssens, M., Van Renterghem, B., Bourgois, J., Vrijens, J., Philippaerts, R.M. British journal of sports medicine. (2006) [Pubmed]
 
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