Disease relevance of RNU13P1

• The backbone torsion angles, which partially influence the local conformation of U12 and U14 in U1 and U3-hairpins, respectively, are probably locked in the trans conformation as in the case of U13 in the U2-hairpin [1].

High impact information on RNU13P1

• The U3, U8 and U13 snoRNA genes are transcribed independently, whereas U14-U24, as well as E3, are located within introns of protein-coding genes, most of whose functions are linked to translation [2].
• Fractionation of HeLa cells revealed that U8 and U13, like U3, reside in the nucleolus [3].
• U3, U8 and U13 comprise a new class of mammalian snRNPs localized in the cell nucleolus [3].
• We propose that U3, U8 and U13 comprise a new subset of mammalian snRNPs whose roles in ribosome biogenesis are discussed [3].
• The unassigned sheep syntenic groups U8 and U13 are provisionally assigned to sheep chromosomes 8 and 21, respectively [4].

Biological context of RNU13P1

• Three pseudogenes for human U13 snRNA belong to class III [5].
• These pseudogenes belong to class III because they contain dispersed mismatches when compared to the previously determined U13 RNA sequence, an adenine-rich region at the 3' end, and short imperfect repeats flanking the 5' end of the coding sequence and the 3' end of the adenine-rich region [5].

Analytical, diagnostic and therapeutic context of RNU13P1

• Sequence analysis revealed that one of these RNAs, 136 nucleotides long, is the human U8 homolog; while the other, 105 nucleotides long, represents a novel species which we designate U13 [3].
• METHODS: Anthropometry, maturity status, functional and sport-specific parameters were assessed in elite, sub-elite, and non-elite youth players in four age groups: U13 (n = 117), U14 (n = 136), U15 (n = 138) and U16 (n = 99) [6].

References